Efectos tóxicos del paracetamol en la salud humana y el ambiente

Rosa Leonor Acevedo-Barrios; Carlos Alberto Severiche-Sierra; Jose Del Carmen Jaimes Morales

doi:10.22490/21456453.1845

Vol. 8 No. 1 (2017)

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2017-01-13

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Acevedo-Barrios, R. L., Severiche-Sierra, C. A., & Jaimes Morales, J. D. C. (2017). Efectos tóxicos del paracetamol en la salud humana y el ambiente. Revista De Investigación Agraria Y Ambiental, 8(1), 139-149. https://doi.org/10.22490/21456453.1845

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Efectos tóxicos del paracetamol en la salud humana y el ambiente

DOI: https://doi.org/10.22490/21456453.1845

Section

Artículos de Investigación

Rosa Leonor Acevedo-Barrios Grupo de Investigación en GISAH. Grupo de Investigacion en Estudios Quimicos y Biologicos- Universidad Tecnologica de Bolivar. Cartagena de Indias, Colombia.

Carlos Alberto Severiche-Sierra Grupo de investigacion en Medio Ambiente, Alimentos y Salud MAAS – Universidad de Cartagena. Cartagena de Indias, Colombia.

Jose Del Carmen Jaimes Morales Grupo de investigacion en Medio Ambiente, Alimentos y Salud MAAS – Universidad de Cartagena. Cartagena de Indias, Colombia.

En este artículo se detallan los efectos tóxicos del paracetamol en la salud humana y el ambiente, detallando las generalidades del paracetamol APAP. El metabolismo del APAP y factores potenciales que influyen en su toxicidad, pasando por estudios de toxicidad y por último el destino ambiental. El paracetamol es un analgésico de uso común, presenta alta hidrosolubilidad, eliminándose hasta un 90% por gluconación o sulfación; pero su metabólito N-acetil-para-benzoilquinoneimina en ocasiones se expulsa por medio de las heces y orina, volviéndose un compuesto toxico persistente. Se observan efectos crónicos principalmente en organismos acuáticos, a través de la exposición a diferentes concentraciones de APAP durante un prolongado período de tiempo.

ambiente, contaminación, efectos, salud, tóxicos

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