Control predictivo aplicado a la dosificación automática de insulina en pacientes con diabetes tipo 1

Control engineering influences the modern medicine through robotic surgery, electrophysiological systems (pacemakers and automatic implantable defibrillators), life support systems (ventilators and artificial hearts), and image-guided surgery. An additional area of medicine suited for applications of control is clinical pharmacology, in which.

mathematical modeling plays a prominent role. Although numerous drugs are available for treating disease, proper dosing is often imprecise, resulting in increased costs, morbidity and mortality.

In this work, a potential application of the control engineering to clinical pharmacology, specifically the control of drug dosing is presented. The principal goal is to develop a device in order to control the blood glucose concentration for people with type 1 diabetes, using a predictive control algorithm.

An analysis upon several dynamic relationships between the glucose and the insulin available in the literature must be performed, in order to find and select a proper model for prediction. This model will permit to design an adequate controller.

Finally, the controller robustness will be tested taking into account assumptions as: the algorithm must be applied on different patients and the patient-model could change along the time.