Selecting a spray system for the formation of Eudragit ® S100 microparticles in a fluid bed
The development of microparticles in fluid bed is of high interest in the pharmaceutical, food and agriculture, as this type of formulation to control the release of active ingredients and their stability and functionality by the formation of small solid particles. The fluid bed equipment is commonly used in industry to carry out the process and this can have two sets of spray drying: top spray and bottom spray. In this study we evaluated the two sets of spray drying towards the formation of microparticles of Eudragit®S100. Experiments were conducted toad just the itical process factors and theirevelsusingamultilevel factorial designand working in a Glattfluid bedbrandGmbHD-01277. Factors evaluated were the inlet temperature, the pressure inside he chamber and the flow rate.
The coating material consisted of a methacrylicacid polymer known asEudragit® S100andcore325 meshpowderwasused. The system selected for the microencapsulation was top spray. The spray dryingconditions were set flow rate of4.12 mL/min (flow 8 rpm), inlet temperature of 80ºC and pressure inside the chamber 1 and 3 bars.The microparticles showed homogeneous shapes and sizes, less than 100 microns. The conditions set for the top spray system can be applied to the development of microencapsulation processes of different active ingredients using as polymer Eudragit® S100.
