El deterioro cognitivo como una complicación de la Diabetes Mellitus Tipo 2

Shadye Rocío  Matar-Khalil; Fabio Camilo Rubio-Sandoval

doi:10.22490/24629448.5473

Vol. 19 No. 37 (2021)

Published 2021-12-23

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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Congnitve Impairtent as a Type 2 Diabestes Mellitus complication

DOI: https://doi.org/10.22490/24629448.5473

Shadye Rocío Matar-Khalil Universidad Nacional Abierta y a Distancia

Rubio-Sandoval Rubio-Sandoval

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Abstract
References

Introduction: Diabetes mellitus is a complex and chronic disease that has an impact on public health due to its high prevalence, the implicit economic cost and associated complications like cognitive alterations. Methodology: A review of the topic was carried out across national and international literature in databases of social sciences and health sciences between the years 1990-2019 that expose the possible association between diabetes mellitus and cognitive impairment, as well as the possible routes that lead to cognitive alterations. Results: The consulted literature exposed a link between diabetes mellitus and complications of the central nervous system, neurological lesions, attention capacity deficiencies, memory loss, cognitive impairment, and a considerable increase in the risk of developing dementia and Alzheimer's type dementia. Conclusions: The progressive nature of both diabetes mellitus, and associated vascular risk, suggest the need for prevention of cognitive impairment based on a comprehensive evaluation that includes neuropsychological tests within routine examinations in patients diagnosed with diabetes mellitus.

keywords: Cognition, diabetes mellitus, diabetes complications

Federación Internacional de la Diabetes. Atlas de la Diabetes de la FDI, novena edición. Bruselas, Bélgica; 2019. Disponible en: https://www.diabetesatlas.org

Ogurtsova K; da Rocha-Fernandes J; Huang Y; Linnenkamp U; Guariguata L; Cho N; et al. IDF Diabetes Atlas: Global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes Res Clin Pract. 2017 Jun; 128:40-50. https://www.diabetesresearchclinicalpractice.com/article/S0168-8227(17)30375-3/fulltext

Organización Mundial de la Salud - OMS. Informe mundial sobre la diabetes. Ginebra, Suiza; 2016. Disponibel en: https://apps.who.int/iris/bitstream/handle/10665/254649/9789243565255-spa.pdf;jsessionid=3D676CEB4FC964428007FCD1B1EFD8E8?sequence=1

Federación Internacional de la Diabetes - IDF. Atlas de la diabetes de la FDI, séptima edición. Bruselas, Bélgica; 2015. Disponible en: https://www.idf.org/e-library/epidemiology-research/diabetes-atlas

Ministerio de Salud y Protección Social, y Departamento Administrativo de Ciencia, Tecnología e Innovación - Colciencias. Guía de práctica clínica para el diagnóstico, tratamiento y seguimiento de la diabetes mellitus tipo 2 en la población mayor de 18 años, Guía No. GPC-2015-51. Bogotá; 2016. Disponible en:

http://gpc.minsalud.gov.co/gpc_sites/Repositorio/Conv_637/GPC_diabetes/Guia_Diabetes_Profesionales_Tipo_2.pdf

Murray RK, Bender DA, Botham KM, Kennelly PJ, Rodwell VW, Weil PA. Harper Bioquímica ilustrada. 28ª edición. México: McGRAW-Hill Interamericana Editores, S.A; 2010. pp. 131-142.

American Diabetes Association - ADA. Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 2011; 34(1):S62–S69. Disponible en: https://care.diabetesjournals.org/content/34/Supplement_1/

Asociación Panamericana de Oftalmología – APAO; Programa Visión 2020/IAPB Latinoamérica; Consejo Internacional de Oftalmología - ICO. Actualización de la Guía clínica de Retinopatía Diabética para Latinoamérica. Buenos Aires; 2016. Disponible en: https://oftalmologos.org.ar/noticias/620-actualizacion-de-la-guia-de-retinopatia-diabetica.

Campuzano-Maya MG; Latorre-Sierra G. La HbA1c en el diagnóstico y en el manejo de la diabetes. Medicina & Laboratorio, 2010; 16:211-241. https://biblat.unam.mx/hevila/Medicinalaboratorio/2010/vol16/no5-6/1.

Miles WR; Root HF. Psychologic tests applied to diabetic patients. Arch Intern Med, 1992; 30(6):767–777. https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/534090

Dejgaard A; Gade A; Larsson H; Balle V; Parving A; Parving H. Evidence for diabetic encephalopathy. Diabet Med. 1991; 8(2):162–167. https://onlinelibrary.wiley.com/toc/14645491/1991/8/2

Gaudieri PA; Chen R; Greer TF; Holmes CS. Cognitive function in children with type 1 diabetes: a meta-analysis. Diabetes care. 2008; 31(9):1892–1897. https://care.diabetesjournals.org/content/31/9/1892.short#aff-1

Lu FP; Lin KP; Kuo HK. Diabetes and the risk of multi-system aging phenotypes: a systematic review and meta-analysis. PLoS One. 2009; 4(1), e4144. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0004144

Cheng G; Huang C; Deng H; Wang H. Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies. Intern Med J. 2012; 42(5):484-91. https://onlinelibrary.wiley.com/toc/14455994/2012/42/5

Nooyens A; Baan CA; Spijkerman A; Verschuren WM. Type 2 diabetes and cognitive decline in middle-aged men and women: the Doetinchem Cohort Study. Diabetes Care. 2010; 33(9):1964-9. https://care.diabetesjournals.org/content/33/9/1964

Stratton IM; Adler AI; Neil HAW; Mattews DR; Manley SE; Cull CA; et al. Association of glucaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): Propspective observational study. BMJ. 2000; 321:405-12. https://www.bmj.com/content/321/7258/405

Testa R; Bonfigli AR; Prattichizzo F; La Sala L; De Nigris V; Ceriello A. The "Metabolic Memory" Theory and the Early Treatment of Hyperglycemia in Prevention of Diabetic Complications. Nutrients. 2017; 9(5):437. https://www.mdpi.com/2072-6643/9/5/437

Gorska-Ciebiada M; Saryusz-Wolska M; Borkowska A; Ciebiada M; Loba J. (2015). C-Reactive Protein, Advanced Glycation End Products, and Their Receptor in Type 2 Diabetic, Elderly Patients with Mild Cognitive Impairment. Front. Aging Neurosci. 2015; 7:209. https://www.frontiersin.org/articles/10.3389/fnagi.2015.00209/full

Ho N; Sommers MS; Lucki I. Effects of Diabetes on Hippocampal Neurogenesis: Links to Cognition and Depression. Neurosci Biobehav Rev. 2013; 37(8): 1346–1362. https://www.sciencedirect.com/science/article/abs/pii/S0149763413000705

McEwen BS. Protective and damaging effects of stress mediators: central role of the brain. Dialogues Clin Neurosci. 2006; 8(4):367–381 https://www.dialogues-cns.org/contents-8-4/

McNay EC; Recknagel AK. Brain insulin signaling. A key componet of cognitive processes and a potential basis for cognitive impairment in type 2 diabetes. Neurobiol Learn Mem. 2011; 96(3):432-442. https://www.sciencedirect.com/science/article/abs/pii/S1074742711001493

Li W; Huang E. An update on type 2 diabetes mellitus as a risk factor for dementia. J. Alzheimers. Dis. 2016; 53(2): 393-402. https://www.j-alz.com/vol53-2

Brands AM; Biessels GJ; Kappelle LJ; de Haan EH; de Valk HW; Algra A; et al. Cognitive functioning and brain MRI in patients with type 1 and type 2 diabetes mellitus: a comparative study. Dement Geriatr Cogn Disord. 2007; 23(5):343–350. https://www.karger.com/Article/Abstract/100980

Reijmer YD; Brundel M; de Bresser J; Kappele LJ; Leemans A; Biessels GJ. (2013). Microstructural White Matter Abnormalities and Cognitive Funcioning in Type 2 Diabetes. Diabetes Care. 2013; 36(1):137–144. https://care.diabetesjournals.org/content/36/1/137

Strachan MWJ; Deary IJ; Ewing FME; Frier BM. Is type II diabetes associated with an increased risk of cognitive dysfunction? A critical review of published studies. Diabetes Care. 1997; 20(3):438–445. https://care.diabetesjournals.org/content/20/3/438

American Diabetes Association - ADA. Standards of medical care in diabetes-2017: Summary of Revisións. Diabetes Care. 2017; 40(1):S4-S5. https://care.diabetesjournals.org/content/40/Supplement_1/S4

Federación Internacional de la Diabetes - IDF. IDF Clinical Practice Recommendations for managing Type 2 Diabetes in Primary Care. Bruselas, Belgica; 2017. Disponible en: https://idf.org/our-activities/advocacy-awareness/resources-and-tools/128:idf-clinical-practice-recommendations-for-managing-type-2-diabetes-in-primary-care.html

Inzucchi SE; Bergenstal RM; Buse JB; Diamant M; Ferrannini E; Nauck M; et al. Management of hyperglycaemia in type 2 diabetes, 2015: a patient-centred approach. Update to a Position Statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2015; 38(1):140–149. https://care.diabetesjournals.org/content/38/1/140

Sternberg RJ; Sternberg K. Cognitive Spychology, Sixth edition. Belmont, California.: Wadsworth, Cengage Learning.; 2012.

Neisser U. Cognitive psychology. Englewood Cliffs, USA: Prentice-Hall.; 1967.

Hyman, I. The ralling cry for the cognitive revolution. En: Neisser U. Cognitive Psychology: Classic Edition. New York: Psychology Press; 2014. p. XV-XIX.

Neisser U. Cognitive psychology: Classic Edition. New York, USA.: Psychology Press.; 2014.

Strachan MWJ. R D Lawrence Lecture 2010. The brain as a target organ in Type 2 diabetes: exploring the links with cognitive impairment and dementia. Diabet Med. 2011; 28(2):141–147. https://onlinelibrary.wiley.com/doi/full/10.1111/j.1464-5491.2010.03199.x

Ryan CM; Geckle MO; Orchard TJ; Cognitive efficiency declines over time in adults with Type 1 diabetes: effects of micro- and macrovascular complications. Diabetologia. 2003; 46(7):940–948. https://link.springer.com/article/10.1007/s00125-003-1128-2

Brands AMA; Biessels GJ; de Haan EH; Kappelle LJ; Kessels RP. The effects of type 1 diabetes on cognitive performance: a meta-analysis. Diabetes Care. 2005;28(3):726–735. https://care.diabetesjournals.org/content/28/3/726.long

Kodl CT; Seaquist ER. Cognitive dysfunction and diabetes mellitus. Endocr Rev. 2008; 29(4):494–511. https://academic.oup.com/edrv/article/29/4/494/2355063

Wrighten SA; Piroli GG; Grillo CA; Reagan LP. A look inside the diabetic brain: Contributors to diabetes-induced brain aging. Biochim Biophys Acta. 2009; 1792(5):444–453. https://www.sciencedirect.com/science/article/pii/S092544390800210X?via%3Dihub

Jacobson AM; Musen G; Ryan CM; Silvers N; Cleary P; Waberski B. Long-term effect of diabetes and its treatment on cognitive function. N Engl J Med. 2007; 356(18):1842–52. https://www.nejm.org/doi/full/10.1056/nejmoa066397

Díaz-Venegas C; Schneider DC; Myrskylä M; Mehta NK. Life expectancy with and without cognitive impairment by diabetes status among older Americans. PLoS One [Internet]. 2017 [consultado 30 de marzo de 2018]; 12(12). Disponible en: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0190488

Fontbonne A; Berr C; Ducimetière P; Alpérovitch, A. Changes in cognitive abilities over a 4-year period are unfavorably affected in elderly diabetic subjects: results of the Epidemiology of Vascular Aging Study. Diabetes Care. 2001; 24(2):366–370. https://care.diabetesjournals.org/content/24/2/366

Van den Berg E; Reijmer YD; de Bresser J; Kessels RP; Kappelle LJ; Biessels GJ; et al. A 4 year follow-up study of cognitive functioning in patients with type 2 diabetes mellitus. Diabetología. 2010; 53(1):58–65. https://link.springer.com/article/10.1007/s00125-009-1571-9

Velayudhan L; Poppe M; Archer N; Proitsi P; Brown RG; Lovestone S. Risk of developing dementia in people with diabetes and mild cognitive impairment. Br J Psychiatry. 2010; 196(1):36–40. https://www.cambridge.org/core/journals/the-british-journal-of-psychiatry/article/risk-of-developing-dementia-in-people-with-diabetes-and-mild-cognitive-impairment/66FC681F46B03CBC17AAAE0A6B4E030B

Novik V; García S; Heller F; Mercado J. Influencia de la Diabetes Mellitus tipo 2 en el deterioro cognitivo en un grupo de adultos mayores. Rev. chil. endocrinol. diabetes. 2011; 4 (1):13-17. http://www.revistasoched.cl/1_2011/index-1-2011.html

Heidari M; Ghahremanlu H; Haghshenas M; Sadeghi M; Heidari A. Comparison of memory impairments among two groups of patients with diabetes with different disease durations. BMC Research Notes. 2012; 5:353. http://www.biomedcentral.com/1756-0500/5/353

Pourabbasi A; Tehrani-Doost M; Qavam SE; Farzami J; Larijani B. Evaluation of Cognitive Functions in Iranian Children and Adolescents with Diabetes Mellitus. Acta Med Iran. 2017; 55(6):381-388. https://acta.tums.ac.ir/index.php/acta/article/view/6197

Kern W; Peters A; Fruehwald-Schultes B; Deninger E; Fehm HL. Improving influence of insulin on cognitive dunctions in humans. Neuroendocrinology. 2001; 74(4):270-280. https://www.karger.com/Article/Abstract/54694

Rudner M; Fransson P; Ingvar M; Nyberg L; Rönnberg J. Neural representation of binding lexical signs and words in the episodic buffer of working memory. Neuropsychologia, 2007; 45(10):2258–2276. https://www.sciencedirect.com/science/article/abs/pii/S0028393207000772?via%3Dihub

Willette AA; Bendlin BB; Starks EJ; Birdsill AC; Johnson SC; Christian BT. Association of Insulin Resistance with Cerebral Glucose Uptake in Late Middle–Aged Adults at Risk for Alzheimer Disease. JAMA Neurol. 2015; 72(9):1013-1020. https://jamanetwork.com/journals/jamaneurology/fullarticle/2398420

Zhao W; Chen H; Xu H; Moore E; Meiri N; Quon MJ; et al. Brain insulin receptors and spatial memory. Correlated changes in gene expression, tyrosine phosphorylation, and signaling molecules in the hippocampus of water maze trained rats. J Biol Chem. 1999; 274(49). https://www.jbc.org/content/274/49/34893.long

Moran C; Beare R; Phan TG; Bruce DG; Callisaya ML; Srikanth V. Type 2 diabetes mellitus and biomarkers of neurodegeneration. Neurology. 2015; 85(13):1123-30. https://n.neurology.org/content/85/13/1123.long

Moran C; Phan TG; Chen J; Blizzard L; Beare R; Venn A; Srikanth V. Brain atrophy in Type 2 diabetes: regional distribution and influence on cognition. Diabetes Care. 2013; 36(12):4036–4042. https://care.diabetesjournals.org/content/36/12/4036

Qiu C; Sigurdsson S; Zhang Q; Jonsdottir M K; Kjartansson O; Eiriksdottir G; Launer LJ. Diabetes, markers of brain pathology and cognitive function: the age, gene/environment susceptibility-Reykjavik study. Ann Neurol. 2014; 75(1):138–146. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540233/

Callisaya ML; Daly RM; Sharman JE; Bruce D; Davis TME; Greenaway T; et al. Feasibility of a multi-modal exercise program on cognition in older adults with Type 2 diabetes - a pilot randomised controlled trial. BMC Geriatr. 2017; 17(1). https://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877-017-0635-9

Kalousová M; Skrha J; Zima T. Advanced glycation end-products and advanced oxidation protein products in patients with diabetes mellitus. Physiol Res, 2002; 51(6):597-604. https://pubmed.ncbi.nlm.nih.gov/12511184/

Krapfenbauer K; Birnbacher R; Vierhapper H; Herkner K; Kampel D; Lubec G. Glycoxidation, and protein and DNA oxidation in patients with diabetes mellitus. Clin Sci (Lond). 1998; 95(3):331-337. https://pubmed.ncbi.nlm.nih.gov/9730853/

Nowotny K; Jung T; Höhn A; Weber D; Grune T. Advanced glycation end products and oxidative stress in type 2 diabetes mellitus. Biomolecules. 2015;5(1):194-222. https://www.mdpi.com/2218-273X/5/1/194

Sinclair AJ; Girling A J; Bayer A. Cognitive dysfunction in older subjects with diabetes mellitus: impact on diabetes selfmanagement and use of care services. Diabetes Res Clin Pract, 2000;50(3):203–212. https://www.diabetesresearchclinicalpractice.com/article/S0168-8227(00)00195-9/fulltext

Formiga F; Reñe R; Pérez M. Dementia and diabetes: Casual or Causal Relationship?. Rev. Med. Clin. (Barc), 2015;144(4):176-80. https://www.elsevier.es/es-revista-medicina-clinica-2-linkresolver-demencia-diabetes-relacion-casual-o-S0025775314001195

Dominguez RO; Pagano MA; Marschoff ER; González SE; Repetto MG; Serra JA. Enfermedad de Alzheimer y detorio cognitivo asociado a la diabetes mellitus tipo 2: relaciones e hipótesis. Revista de Neurología. 2014; 29(9):567-572. https://www.elsevier.es/es-revista-neurologia-295-articulo-enfermedad-alzheimer-deterioro-cognitivo-asociado-S0213485313001552

Roriz-Filho SJ; Sa-Roriz TM; Rosset I; Camozzato AL; Santos AC; Chaves ML; et al. (Pre)diabetes, brain aging, and cognition. Biochim Biophys Acta. 2009; 1792(5):432–43. https://www.sciencedirect.com/science/article/pii/S0925443908002524?via%3Dihub

You CJ; Liu D; Liu LL; Li GZ. Correlation between acute stroke-induced white matter lesions and insulin resistance. Medicine (Baltimore). 2018; 97(11):e9860. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882385/

Rundek T; Gardener H; Xu Q; Goldberg RB; Wright CB; Boden-Albala B; et al. Insulin resistance and risk of ischemic stroke among nondiabetic individuals from the northern Manhattan study. Arch Neurol. 2010; 67(10):1195–200. https://jamanetwork.com/journals/jamaneurology/fullarticle/801407

Anan F; Masaki T; Kikuchi H; Iwao T; Shimomura T; Umeno Y; et al. Association between plasma highsensitivity C-reactive protein and insulin resistance and white matter lesion in Japanese type 2 diabetic patients. Diabetes Res Clin Pract. 2010; 87(2):233–239. https://www.diabetesresearchclinicalpractice.com/article/S0168-8227(09)00465-3/fulltext

Feinkohl I; Aung PP; Keller M; Robertson CM; Morling JR; McLachlan S; et al. Severe hypoglycemia and cognitive decline in older people with type 2 diabetes: The Edinburgh type 2 diabetes study. Diabetes Care. 2014; 37(2):507-515. https://care.diabetesjournals.org/content/37/2/507.long

Colberg SR; Somma CT; Sechrist SR. Physical Activity Participation May Offset Some of the Negative Impact of Diabetes on Cognitive Function. J. Am. Med. Dir. Assoc. 2008; 9(6):434–438. https://www.jamda.com/article/S1525-8610(08)00121-7/fulltext

Blondell SJ; Hammerseley-Mather R; Veerman JL. Does physical activity prevent cognitive decline and dementia A sistematic review and meta-analysis of longitudinal studies. BMC Public Health. 2014; 14(510). https://bmcpublichealth.biomedcentral.com/articles/10.1186/1471-2458-14-510

Hernández RJ; Domínguez YA; Mendoza-Choqueticlla J. Efectos benéficos del ejercicio físico en las personas con diabetes mellitus tipo 2. Rev. Cuba. Endoc. 2018; 29(2):1-18. https://www.medigraphic.com/cgi-bin/new/resumen.cgi?IDARTICULO=84725

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Matar-Khalil, S. R. ., & Rubio-Sandoval , R.-S. . (2021). Congnitve Impairtent as a Type 2 Diabestes Mellitus complication. NOVA Biomedical Sciences Journal, 19(37), 25-41. https://doi.org/10.22490/24629448.5473

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Congnitve Impairtent as a Type 2 Diabestes Mellitus complication

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