Congnitve Impairtent as a Type 2 Diabestes Mellitus complication
Introduction: Diabetes mellitus is a complex and chronic disease that has an impact on public health due to its high prevalence, the implicit economic cost and associated complications like cognitive alterations. Methodology: A review of the topic was carried out across national and international literature in databases of social sciences and health sciences between the years 1990-2019 that expose the possible association between diabetes mellitus and cognitive impairment, as well as the possible routes that lead to cognitive alterations. Results: The consulted literature exposed a link between diabetes mellitus and complications of the central nervous system, neurological lesions, attention capacity deficiencies, memory loss, cognitive impairment, and a considerable increase in the risk of developing dementia and Alzheimer's type dementia. Conclusions: The progressive nature of both diabetes mellitus, and associated vascular risk, suggest the need for prevention of cognitive impairment based on a comprehensive evaluation that includes neuropsychological tests within routine examinations in patients diagnosed with diabetes mellitus.
Federación Internacional de la Diabetes. Atlas de la Diabetes de la FDI, novena edición. Bruselas, Bélgica; 2019. Disponible en: https://www.diabetesatlas.org
Ogurtsova K; da Rocha-Fernandes J; Huang Y; Linnenkamp U; Guariguata L; Cho N; et al. IDF Diabetes Atlas: Global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes Res Clin Pract. 2017 Jun; 128:40-50. https://www.diabetesresearchclinicalpractice.com/article/S0168-8227(17)30375-3/fulltext
Organización Mundial de la Salud - OMS. Informe mundial sobre la diabetes. Ginebra, Suiza; 2016. Disponibel en: https://apps.who.int/iris/bitstream/handle/10665/254649/9789243565255-spa.pdf;jsessionid=3D676CEB4FC964428007FCD1B1EFD8E8?sequence=1
Federación Internacional de la Diabetes - IDF. Atlas de la diabetes de la FDI, séptima edición. Bruselas, Bélgica; 2015. Disponible en: https://www.idf.org/e-library/epidemiology-research/diabetes-atlas
Ministerio de Salud y Protección Social, y Departamento Administrativo de Ciencia, Tecnología e Innovación - Colciencias. Guía de práctica clínica para el diagnóstico, tratamiento y seguimiento de la diabetes mellitus tipo 2 en la población mayor de 18 años, Guía No. GPC-2015-51. Bogotá; 2016. Disponible en:
Murray RK, Bender DA, Botham KM, Kennelly PJ, Rodwell VW, Weil PA. Harper Bioquímica ilustrada. 28ª edición. México: McGRAW-Hill Interamericana Editores, S.A; 2010. pp. 131-142.
American Diabetes Association - ADA. Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 2011; 34(1):S62–S69. Disponible en: https://care.diabetesjournals.org/content/34/Supplement_1/
Asociación Panamericana de Oftalmología – APAO; Programa Visión 2020/IAPB Latinoamérica; Consejo Internacional de Oftalmología - ICO. Actualización de la Guía clínica de Retinopatía Diabética para Latinoamérica. Buenos Aires; 2016. Disponible en: https://oftalmologos.org.ar/noticias/620-actualizacion-de-la-guia-de-retinopatia-diabetica.
Campuzano-Maya MG; Latorre-Sierra G. La HbA1c en el diagnóstico y en el manejo de la diabetes. Medicina & Laboratorio, 2010; 16:211-241. https://biblat.unam.mx/hevila/Medicinalaboratorio/2010/vol16/no5-6/1.
Miles WR; Root HF. Psychologic tests applied to diabetic patients. Arch Intern Med, 1992; 30(6):767–777. https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/534090
Dejgaard A; Gade A; Larsson H; Balle V; Parving A; Parving H. Evidence for diabetic encephalopathy. Diabet Med. 1991; 8(2):162–167. https://onlinelibrary.wiley.com/toc/14645491/1991/8/2
Gaudieri PA; Chen R; Greer TF; Holmes CS. Cognitive function in children with type 1 diabetes: a meta-analysis. Diabetes care. 2008; 31(9):1892–1897. https://care.diabetesjournals.org/content/31/9/1892.short#aff-1
Lu FP; Lin KP; Kuo HK. Diabetes and the risk of multi-system aging phenotypes: a systematic review and meta-analysis. PLoS One. 2009; 4(1), e4144. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0004144
Cheng G; Huang C; Deng H; Wang H. Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies. Intern Med J. 2012; 42(5):484-91. https://onlinelibrary.wiley.com/toc/14455994/2012/42/5
Nooyens A; Baan CA; Spijkerman A; Verschuren WM. Type 2 diabetes and cognitive decline in middle-aged men and women: the Doetinchem Cohort Study. Diabetes Care. 2010; 33(9):1964-9. https://care.diabetesjournals.org/content/33/9/1964
Stratton IM; Adler AI; Neil HAW; Mattews DR; Manley SE; Cull CA; et al. Association of glucaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): Propspective observational study. BMJ. 2000; 321:405-12. https://www.bmj.com/content/321/7258/405
Testa R; Bonfigli AR; Prattichizzo F; La Sala L; De Nigris V; Ceriello A. The "Metabolic Memory" Theory and the Early Treatment of Hyperglycemia in Prevention of Diabetic Complications. Nutrients. 2017; 9(5):437. https://www.mdpi.com/2072-6643/9/5/437
Gorska-Ciebiada M; Saryusz-Wolska M; Borkowska A; Ciebiada M; Loba J. (2015). C-Reactive Protein, Advanced Glycation End Products, and Their Receptor in Type 2 Diabetic, Elderly Patients with Mild Cognitive Impairment. Front. Aging Neurosci. 2015; 7:209. https://www.frontiersin.org/articles/10.3389/fnagi.2015.00209/full
Ho N; Sommers MS; Lucki I. Effects of Diabetes on Hippocampal Neurogenesis: Links to Cognition and Depression. Neurosci Biobehav Rev. 2013; 37(8): 1346–1362. https://www.sciencedirect.com/science/article/abs/pii/S0149763413000705
McEwen BS. Protective and damaging effects of stress mediators: central role of the brain. Dialogues Clin Neurosci. 2006; 8(4):367–381 https://www.dialogues-cns.org/contents-8-4/
McNay EC; Recknagel AK. Brain insulin signaling. A key componet of cognitive processes and a potential basis for cognitive impairment in type 2 diabetes. Neurobiol Learn Mem. 2011; 96(3):432-442. https://www.sciencedirect.com/science/article/abs/pii/S1074742711001493
Li W; Huang E. An update on type 2 diabetes mellitus as a risk factor for dementia. J. Alzheimers. Dis. 2016; 53(2): 393-402. https://www.j-alz.com/vol53-2
Brands AM; Biessels GJ; Kappelle LJ; de Haan EH; de Valk HW; Algra A; et al. Cognitive functioning and brain MRI in patients with type 1 and type 2 diabetes mellitus: a comparative study. Dement Geriatr Cogn Disord. 2007; 23(5):343–350. https://www.karger.com/Article/Abstract/100980
Reijmer YD; Brundel M; de Bresser J; Kappele LJ; Leemans A; Biessels GJ. (2013). Microstructural White Matter Abnormalities and Cognitive Funcioning in Type 2 Diabetes. Diabetes Care. 2013; 36(1):137–144. https://care.diabetesjournals.org/content/36/1/137
Strachan MWJ; Deary IJ; Ewing FME; Frier BM. Is type II diabetes associated with an increased risk of cognitive dysfunction? A critical review of published studies. Diabetes Care. 1997; 20(3):438–445. https://care.diabetesjournals.org/content/20/3/438
American Diabetes Association - ADA. Standards of medical care in diabetes-2017: Summary of Revisións. Diabetes Care. 2017; 40(1):S4-S5. https://care.diabetesjournals.org/content/40/Supplement_1/S4
Federación Internacional de la Diabetes - IDF. IDF Clinical Practice Recommendations for managing Type 2 Diabetes in Primary Care. Bruselas, Belgica; 2017. Disponible en: https://idf.org/our-activities/advocacy-awareness/resources-and-tools/128:idf-clinical-practice-recommendations-for-managing-type-2-diabetes-in-primary-care.html
Inzucchi SE; Bergenstal RM; Buse JB; Diamant M; Ferrannini E; Nauck M; et al. Management of hyperglycaemia in type 2 diabetes, 2015: a patient-centred approach. Update to a Position Statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2015; 38(1):140–149. https://care.diabetesjournals.org/content/38/1/140
Sternberg RJ; Sternberg K. Cognitive Spychology, Sixth edition. Belmont, California.: Wadsworth, Cengage Learning.; 2012.
Neisser U. Cognitive psychology. Englewood Cliffs, USA: Prentice-Hall.; 1967.
Hyman, I. The ralling cry for the cognitive revolution. En: Neisser U. Cognitive Psychology: Classic Edition. New York: Psychology Press; 2014. p. XV-XIX.
Neisser U. Cognitive psychology: Classic Edition. New York, USA.: Psychology Press.; 2014.
Strachan MWJ. R D Lawrence Lecture 2010. The brain as a target organ in Type 2 diabetes: exploring the links with cognitive impairment and dementia. Diabet Med. 2011; 28(2):141–147. https://onlinelibrary.wiley.com/doi/full/10.1111/j.1464-5491.2010.03199.x
Ryan CM; Geckle MO; Orchard TJ; Cognitive efficiency declines over time in adults with Type 1 diabetes: effects of micro- and macrovascular complications. Diabetologia. 2003; 46(7):940–948. https://link.springer.com/article/10.1007/s00125-003-1128-2
Brands AMA; Biessels GJ; de Haan EH; Kappelle LJ; Kessels RP. The effects of type 1 diabetes on cognitive performance: a meta-analysis. Diabetes Care. 2005;28(3):726–735. https://care.diabetesjournals.org/content/28/3/726.long
Kodl CT; Seaquist ER. Cognitive dysfunction and diabetes mellitus. Endocr Rev. 2008; 29(4):494–511. https://academic.oup.com/edrv/article/29/4/494/2355063
Wrighten SA; Piroli GG; Grillo CA; Reagan LP. A look inside the diabetic brain: Contributors to diabetes-induced brain aging. Biochim Biophys Acta. 2009; 1792(5):444–453. https://www.sciencedirect.com/science/article/pii/S092544390800210X?via%3Dihub
Jacobson AM; Musen G; Ryan CM; Silvers N; Cleary P; Waberski B. Long-term effect of diabetes and its treatment on cognitive function. N Engl J Med. 2007; 356(18):1842–52. https://www.nejm.org/doi/full/10.1056/nejmoa066397
Díaz-Venegas C; Schneider DC; Myrskylä M; Mehta NK. Life expectancy with and without cognitive impairment by diabetes status among older Americans. PLoS One [Internet]. 2017 [consultado 30 de marzo de 2018]; 12(12). Disponible en: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0190488
Fontbonne A; Berr C; Ducimetière P; Alpérovitch, A. Changes in cognitive abilities over a 4-year period are unfavorably affected in elderly diabetic subjects: results of the Epidemiology of Vascular Aging Study. Diabetes Care. 2001; 24(2):366–370. https://care.diabetesjournals.org/content/24/2/366
Van den Berg E; Reijmer YD; de Bresser J; Kessels RP; Kappelle LJ; Biessels GJ; et al. A 4 year follow-up study of cognitive functioning in patients with type 2 diabetes mellitus. Diabetología. 2010; 53(1):58–65. https://link.springer.com/article/10.1007/s00125-009-1571-9
Velayudhan L; Poppe M; Archer N; Proitsi P; Brown RG; Lovestone S. Risk of developing dementia in people with diabetes and mild cognitive impairment. Br J Psychiatry. 2010; 196(1):36–40. https://www.cambridge.org/core/journals/the-british-journal-of-psychiatry/article/risk-of-developing-dementia-in-people-with-diabetes-and-mild-cognitive-impairment/66FC681F46B03CBC17AAAE0A6B4E030B
Novik V; García S; Heller F; Mercado J. Influencia de la Diabetes Mellitus tipo 2 en el deterioro cognitivo en un grupo de adultos mayores. Rev. chil. endocrinol. diabetes. 2011; 4 (1):13-17. http://www.revistasoched.cl/1_2011/index-1-2011.html
Heidari M; Ghahremanlu H; Haghshenas M; Sadeghi M; Heidari A. Comparison of memory impairments among two groups of patients with diabetes with different disease durations. BMC Research Notes. 2012; 5:353. http://www.biomedcentral.com/1756-0500/5/353
Pourabbasi A; Tehrani-Doost M; Qavam SE; Farzami J; Larijani B. Evaluation of Cognitive Functions in Iranian Children and Adolescents with Diabetes Mellitus. Acta Med Iran. 2017; 55(6):381-388. https://acta.tums.ac.ir/index.php/acta/article/view/6197
Kern W; Peters A; Fruehwald-Schultes B; Deninger E; Fehm HL. Improving influence of insulin on cognitive dunctions in humans. Neuroendocrinology. 2001; 74(4):270-280. https://www.karger.com/Article/Abstract/54694
Rudner M; Fransson P; Ingvar M; Nyberg L; Rönnberg J. Neural representation of binding lexical signs and words in the episodic buffer of working memory. Neuropsychologia, 2007; 45(10):2258–2276. https://www.sciencedirect.com/science/article/abs/pii/S0028393207000772?via%3Dihub
Willette AA; Bendlin BB; Starks EJ; Birdsill AC; Johnson SC; Christian BT. Association of Insulin Resistance with Cerebral Glucose Uptake in Late Middle–Aged Adults at Risk for Alzheimer Disease. JAMA Neurol. 2015; 72(9):1013-1020. https://jamanetwork.com/journals/jamaneurology/fullarticle/2398420
Zhao W; Chen H; Xu H; Moore E; Meiri N; Quon MJ; et al. Brain insulin receptors and spatial memory. Correlated changes in gene expression, tyrosine phosphorylation, and signaling molecules in the hippocampus of water maze trained rats. J Biol Chem. 1999; 274(49). https://www.jbc.org/content/274/49/34893.long
Moran C; Beare R; Phan TG; Bruce DG; Callisaya ML; Srikanth V. Type 2 diabetes mellitus and biomarkers of neurodegeneration. Neurology. 2015; 85(13):1123-30. https://n.neurology.org/content/85/13/1123.long
Moran C; Phan TG; Chen J; Blizzard L; Beare R; Venn A; Srikanth V. Brain atrophy in Type 2 diabetes: regional distribution and influence on cognition. Diabetes Care. 2013; 36(12):4036–4042. https://care.diabetesjournals.org/content/36/12/4036
Qiu C; Sigurdsson S; Zhang Q; Jonsdottir M K; Kjartansson O; Eiriksdottir G; Launer LJ. Diabetes, markers of brain pathology and cognitive function: the age, gene/environment susceptibility-Reykjavik study. Ann Neurol. 2014; 75(1):138–146. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540233/
Callisaya ML; Daly RM; Sharman JE; Bruce D; Davis TME; Greenaway T; et al. Feasibility of a multi-modal exercise program on cognition in older adults with Type 2 diabetes - a pilot randomised controlled trial. BMC Geriatr. 2017; 17(1). https://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877-017-0635-9
Kalousová M; Skrha J; Zima T. Advanced glycation end-products and advanced oxidation protein products in patients with diabetes mellitus. Physiol Res, 2002; 51(6):597-604. https://pubmed.ncbi.nlm.nih.gov/12511184/
Krapfenbauer K; Birnbacher R; Vierhapper H; Herkner K; Kampel D; Lubec G. Glycoxidation, and protein and DNA oxidation in patients with diabetes mellitus. Clin Sci (Lond). 1998; 95(3):331-337. https://pubmed.ncbi.nlm.nih.gov/9730853/
Nowotny K; Jung T; Höhn A; Weber D; Grune T. Advanced glycation end products and oxidative stress in type 2 diabetes mellitus. Biomolecules. 2015;5(1):194-222. https://www.mdpi.com/2218-273X/5/1/194
Sinclair AJ; Girling A J; Bayer A. Cognitive dysfunction in older subjects with diabetes mellitus: impact on diabetes selfmanagement and use of care services. Diabetes Res Clin Pract, 2000;50(3):203–212. https://www.diabetesresearchclinicalpractice.com/article/S0168-8227(00)00195-9/fulltext
Formiga F; Reñe R; Pérez M. Dementia and diabetes: Casual or Causal Relationship?. Rev. Med. Clin. (Barc), 2015;144(4):176-80. https://www.elsevier.es/es-revista-medicina-clinica-2-linkresolver-demencia-diabetes-relacion-casual-o-S0025775314001195
Dominguez RO; Pagano MA; Marschoff ER; González SE; Repetto MG; Serra JA. Enfermedad de Alzheimer y detorio cognitivo asociado a la diabetes mellitus tipo 2: relaciones e hipótesis. Revista de Neurología. 2014; 29(9):567-572. https://www.elsevier.es/es-revista-neurologia-295-articulo-enfermedad-alzheimer-deterioro-cognitivo-asociado-S0213485313001552
Roriz-Filho SJ; Sa-Roriz TM; Rosset I; Camozzato AL; Santos AC; Chaves ML; et al. (Pre)diabetes, brain aging, and cognition. Biochim Biophys Acta. 2009; 1792(5):432–43. https://www.sciencedirect.com/science/article/pii/S0925443908002524?via%3Dihub
You CJ; Liu D; Liu LL; Li GZ. Correlation between acute stroke-induced white matter lesions and insulin resistance. Medicine (Baltimore). 2018; 97(11):e9860. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882385/
Rundek T; Gardener H; Xu Q; Goldberg RB; Wright CB; Boden-Albala B; et al. Insulin resistance and risk of ischemic stroke among nondiabetic individuals from the northern Manhattan study. Arch Neurol. 2010; 67(10):1195–200. https://jamanetwork.com/journals/jamaneurology/fullarticle/801407
Anan F; Masaki T; Kikuchi H; Iwao T; Shimomura T; Umeno Y; et al. Association between plasma highsensitivity C-reactive protein and insulin resistance and white matter lesion in Japanese type 2 diabetic patients. Diabetes Res Clin Pract. 2010; 87(2):233–239. https://www.diabetesresearchclinicalpractice.com/article/S0168-8227(09)00465-3/fulltext
Feinkohl I; Aung PP; Keller M; Robertson CM; Morling JR; McLachlan S; et al. Severe hypoglycemia and cognitive decline in older people with type 2 diabetes: The Edinburgh type 2 diabetes study. Diabetes Care. 2014; 37(2):507-515. https://care.diabetesjournals.org/content/37/2/507.long
Colberg SR; Somma CT; Sechrist SR. Physical Activity Participation May Offset Some of the Negative Impact of Diabetes on Cognitive Function. J. Am. Med. Dir. Assoc. 2008; 9(6):434–438. https://www.jamda.com/article/S1525-8610(08)00121-7/fulltext
Blondell SJ; Hammerseley-Mather R; Veerman JL. Does physical activity prevent cognitive decline and dementia A sistematic review and meta-analysis of longitudinal studies. BMC Public Health. 2014; 14(510). https://bmcpublichealth.biomedcentral.com/articles/10.1186/1471-2458-14-510
Hernández RJ; Domínguez YA; Mendoza-Choqueticlla J. Efectos benéficos del ejercicio físico en las personas con diabetes mellitus tipo 2. Rev. Cuba. Endoc. 2018; 29(2):1-18. https://www.medigraphic.com/cgi-bin/new/resumen.cgi?IDARTICULO=84725
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