Análisis de la Población de Células T Reguladoras Foxp3 en el Modelo Murino de Amibiasis Intestinal

Claudia Andrea Cruz B.; Juan Pedro Laclette; Mauricio Sarrazola S.

doi:10.22490/24629448.435

Vol. 8 No. 13 (2010)

Published

2010-06-15

PDF (Spanish)

How to Cite

Cruz B., C. A., Laclette, J. P., & Sarrazola S., M. (2010). Analysis of the population of Foxp3 regulatory T cells in the murine model of intestinal amebiasis. NOVA Biomedical Sciences Journal, 8(13), 20-26. https://doi.org/10.22490/24629448.435

Download Citation

Metrics

Metrics Loading ...

Analysis of the population of Foxp3 regulatory T cells in the murine model of intestinal amebiasis

DOI: https://doi.org/10.22490/24629448.435

Section

Research Article (before OJS)

Claudia Andrea Cruz B. Universidad de Pamplona.

Juan Pedro Laclette Universidad Nacional Autónoma de México.

Mauricio Sarrazola S. Universidad de Pamplona.

Amebiasis is a parasitic infection caused by E. histolytica, its incidence is higher in developing countries. Recently we have studied the role of Treg cells in several parasitic diseases, which can have beneficial or harmful. The goal of this project was to investigate the role of Treg cells in an immunosuppressive phenomenon previously observed on mouse model of intestinal amoebiasis. Thus, the behavior of Treg population cells was studied at different periods post-infection. However, the results suggest that Treg cells are not involved in this phenomenon of immunosuppression.

amebiasis, Treg cells, Entamoeba histolytica, splenocytes trophozoites.

Walsh JA. Problems in recognition and diagnosis of amebiasis: estimation of the global magnitud of morbidity and mortality. Rev Infec Dis. 1986;8:228-238.

Ortiz-Ortiz L, Zamacona G, Sepúlveda B, Capín NR. Cell-mediated immunity in patients with amebic abscess of the liver. Clin Immunol Immunopathol. 1975;4:127-34.

Ghosh PK, Castellanos-Barba C, Ortiz-Ortiz L. Intestinal amebiasis: cycli suppression of the immune response. Parasitol Res. 1995;81: 475-480.

GHOSH P., et al. Experimental Amebiasis: Immunohistochemical Study of Immune Cells Populations. J. Eukaryot. Microbiol. 2000;47:395-399.

Maloy, K. J., and Powrie, F. Regulatory T cells in the control of immune pathology. Nat. Immunol. 2001;.2:816–822.

Sakaguchi S, Sakaguchi N, Shimizu J, Yamazaki S, Sakihama T, Itoh M, Kuniyasu Y, Nomura T, Toda M, Takahashi T. Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol. Rev. 2001;182:18–32.

Gavin, M., and Rudensky, A. Control of immune homeostasis by naturally arising regulatory CD4+ T cells. Curr. Opin. Immunol. 2003;15:690–696.

Belkaid, Y., Blank, RB., Suffia, J.. Natural regulatory T cells and parasites: a common quest for host homeostasis. Immunol Rev Review. 2006; 212:287-300.

Hisaeda H, Hamano S, Mitoma-Obata C, Tetsutani K, Imai T, Waldmann H, Himeno K, Yasutomo K. Resistance of regulatory T cells to glucocorticoid-viduced TNFR family-related protein (GITR) during Plasmodium yoelii infection. Eur J Immunol. 2005;35: 3516–3524.

Hesse M, Piccirillo CA, Belkaid Y, Prufer J, Mentink-Kane M, Leusink M, Cheever AW, Shevach EM, Wynn TA. The pathogenesis of schistosomiasis is controlled by cooperating IL-10- producing innate effector and regulatory T cells. J Immunol. 2004;172:3157–3166.

McKee, AS., Pearce, EJ. CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development. J Immunol. 2004;173:1224–1231.

Singh, KP., Gerard, HC., Hudson, AP., Reddy, TR, Boros, DL. Retroviral Foxp3 gene transfer ameliorates liver granuloma pathology in Schistosoma mansoni infected mice. Immunology. 2005;114:410–417.

JI, J., Masterson, J., Sun, J., Soong, L. CD4+CD25+ regulatory T cellsrestrain pathogenic responses during Leishmania amazonensis infection. J Immunol. 2005;174:7147–7153.

Izcue A, Coombes JL, Powrie F. Regulatory T cells suppress systemic and mucosas immune activation to control intestinal inflammation. Immunological Reviews. 2006;212: 256-271.

Download Citation

Published

How to Cite

Analysis of the population of Foxp3 regulatory T cells in the murine model of intestinal amebiasis

Declaración de privacidad.

Keywords