Published
2019-11-15
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Article of Review (before OJS)
Role of mitochondrial-derived peptide humanin as a therapeutic target in cancer and neurodegeneration
Antonela Sofía Asad
Camila Florencia Zuccato
Alejandro Javier Nicola Candia
María Florencia Gottardo
Mariela Alejandra Moreno Ayala
María Susana Theas
Adriana Seilicovich
Marianela Candolfi
Humanin is a mitochondrial-derived peptide which shows robust protective effects against large series of cytotoxic stimuli in many cell types. This makes it an interesting therapeutic target for many diseases, including cancer and neurodegenerative diseases, among others. Furthermore, this peptide could be used as a biomarker for such diseases. Over the last decade, humanin analogs and peptide mimetics have been developed, which exert highly promising results in preclinical models. Besides, the therapeutic potential of gene therapy vectors that overexpress or silence endogenous humanin is under evaluation. Nonetheless, its possible role in cancer progression and chemoresistance are critical issues
to be addressed before translating these therapeutic approaches to the clinic. All these matters will be covered in this review.
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NOVA por http://www.unicolmayor.edu.co/publicaciones/index.php/nova se distribuye bajo una licencia Reconocimiento No Comercial- Compartir igual
Así mismo, los autores mantienen sus derechos de propiedad intelectual sobre los artículos,
Declaración de privacidad.
Los nombres y las direcciones de correo electrónico introducidos en esta revista se usarán exclusivamente para los fines establecidos en ella y no se proporcionarán a terceros o para su uso con otros fines.
Asad, A. S., Zuccato, C. F., Nicola Candia, A. J. ., Gottardo, M. F., Moreno Ayala, M. A., Theas, M. S., Seilicovich, A., & Candolfi, M. . (2019). Role of mitochondrial-derived peptide humanin as a therapeutic target in cancer and neurodegeneration. NOVA Biomedical Sciences Journal, 17(32), 9-24. https://doi.org/10.22490/24629448.3630
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