Complejo mayor de histocompatibilidad y desarrollo de vacunas

Sandra Mónica Estupiñán Torres; MSC; Esperanza Trujillo Gama

doi:10.22490/24629448.9

Vol. 2 Núm. 2 (2004)

Publicado 2004-12-15

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Artículo de Revisión

Complejo mayor de histocompatibilidad y desarrollo de vacunas

DOI: https://doi.org/10.22490/24629448.9

Sandra Mónica Estupiñán Torres; MSC Universidad Colegio Mayor de Cundinamarca.

Esperanza Trujillo Gama Fundación Instituto de Inmunología de Colombia

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Sin duda, las vacunas se constituyen en una alternativa viable y efectiva para el control de las enfermedadesinfectocontagiosas, sin embargo, una estrategia exitosa para el diseño de vacunas debe tener en consideración muchos de los aspectos de la respuesta inmune en una población heterogénea y en su forma de reconocer y presentar los antígenos de los patógenos. Por lo tanto, no solamente el entendimiento preciso de los mecanismos inmunes involucrados en la resistencia a infecciones sino la identificación de las moléculas del patógeno que son el blanco de respuesta protectora, serán motivo central de la investigación en vacunas en el futuro inmediato. El presente artículo de revisión profundiza en el descubrimiento, ubicación, expresión, estructura, herencia, polimorfismo e importancia del complejo mayor de histocompatibilidad; además, presenta los avances en elo uso de primates como modelo para el desarrollo de vacunas.

Palabras clave: vacuna, MHC, histocompatibilidad, primates, herencia, desarrollo.

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Estupiñán Torres; MSC, S. M., & Trujillo Gama, E. (2004). Complejo mayor de histocompatibilidad y desarrollo de vacunas. Revista Nova publicación científica En Ciencias biomédicas, 2(2), 59-70. https://doi.org/10.22490/24629448.9

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