Chemodrug resistance: Cancer’s fight for survival

Jafet  Alcántara Colin; Antonio  Sandoval Cabrera; Daniel Alejandro Martinez Quintero; Jonnathan Guadalupe  Santillán Benítez

doi:10.22490/24629448.7535

Vol. 21 Núm. 41 (21): Número Internacional

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2023-12-16

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Alcántara Colin, J. ., Sandoval Cabrera, A. ., Martinez Quintero, D. A., & Santillán Benítez , J. G. . (2023). Chemodrug resistance: Cancer’s fight for survival. REVISTA NOVA PUBLICACIÓN CIENTÍFICA EN CIENCIAS BIOMÉDICAS, 21(41). https://doi.org/10.22490/24629448.7535

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Chemodrug resistance: Cancer’s fight for survival

DOI: https://doi.org/10.22490/24629448.7535

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Jafet Alcántara Colin Universidad Autónoma del Estado de México https://orcid.org/0009-0005-2324-0597

Antonio Sandoval Cabrera Instituto de Salud del Estado de México

Daniel Alejandro Martinez Quintero Universidad Autónoma del Estado de México

Jonnathan Guadalupe Santillán Benítez https://orcid.org/0000-0003-3574-1231

Introduction. Chemoresistance is a multifactorial phenomenon implicated in all failed therapies and accounts for 90% of all cancer deaths and 30% of relapses. Objective. To understand the genetic mechanisms by which cancer cells acquire resistance to chemo drugs. Methodology. A non-systematic review study was carried out, in which genes and proteins involved in chemoresistance were searched using the terms “Cancer Drug resis- tance [Title/Abstract]”. From the articles obtained, highly involved genes, emerging genes, and proteins related to resistance were recognized. To obtain more specific information about genes, their interactions, and proteins associated with metabolism, the tools “The Human Protein Atlas”, “STRING CONSORTIUM 2022,” and The Small Molecule Pa- thway Database were used for their review. Results. From this review it was found that there are genes highly related to resistance such as: ABCA3, ABCB1, ABCB2, ABCC1, ABCC2, ABCG2, CYP2D6, CYP3A4, GSTA1. Recently recognised genes such as: FOXO3, FOXM1, Skp2, Snail, Twist1, ZEB1 and SLCO1B3. Conclusions. It is necessary to taking account new approaches related to cancer treatments considering chemoresistence and the genes related to the resistence.

Cancer, Resistance, Chemoresistance, Cytochrome P450

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