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Mecanismos fisiopatologicos de la dislipidemia
La dislipidemia corresponde a una alteración de los lípidos en el plasma, lo que significa un aumento de colesterol y/o triglicéridos plasmáticos. Objetivos. Describir los mecanismos fisiopatológicos detrás de la dislipidemia y determinar cómo estos se aplican a los tratamientos. Metodología. Tras una búsqueda bibliográfica exhaustiva de 85 estudios publicados hasta el año 2011, se identificaron los aspectos más importantes tanto de la fisiología, fisiopatología, complicaciones y terapéuticas de esta patología. Resultados. Los mecanismos fisiopatológicos de la dislipidemia se subdividen en mecanismos primarios y secundarios. El tratamiento de la dislipidemia consta de terapias farmacológicas y no farmacológicas, incluyendo en estos últimos, cambios en el estilo de vida que modifiquen la dieta y el ejercicio físico. Dentro de las terapias farmacológicas, se han estudiado a lo largo del tiempo múltiples fármacos y sus interacciones al combinar con otros de estos, siendo los mecanismos más estudiados la inhibición de la síntesis endógena de colesterol, inhibición de la degradación del receptor de LDL, inhibición de la absorción del colesterol, atrapamiento de los ácidos biliares, disminución de la síntesis de lipoproteínas de muy baja densidad y síntesis de triglicéridos. Conclusión.
La dislipidemia se conoce actualmente a nivel más molecular, su correcta compresión nos permite tomar mejores decisiones terapéuticas.
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Derechos de autor 2023 Nova
Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-SinDerivadas 4.0.
NOVA por http://www.unicolmayor.edu.co/publicaciones/index.php/nova se distribuye bajo una licencia Reconocimiento No Comercial- Compartir igual
Así mismo, los autores mantienen sus derechos de propiedad intelectual sobre los artículos,
Declaración de privacidad.
Los nombres y las direcciones de correo electrónico introducidos en esta revista se usarán exclusivamente para los fines establecidos en ella y no se proporcionarán a terceros o para su uso con otros fines.
