Copyright (c) 2024 Cesar Orlando Paz, Jaqueline Mena Huertas, Pablo Fernández Izquierdo, Edith Mariela Burbano-Rosero, Alvaro Pazos
CYP1A1, TNFα Genes and environmental factors associated with gastric cancer in patients from Pasto-Colombia
Introduction. In Pasto, Nariño, Colombian, the gastric cancer (GC) incidence is one of the highest in the world. It is known that in the GC the CYP1A1 and TNFα human susceptibility to cancer genes are involved along to environmental factors to pathogenesis GC. Although the relationship among environmental factors and human genetic predisposition to gastric cancer is still unknown. Aim. To evaluate the environmental factors and GC human genetic predisposition (CYP1A1 and TNFα genes) association in patients with GC diagnose in Pasto. Methods. This is a cross-sectional, descriptive and observational study that included 10 gastric cancers positive and surviving cases. We studied the genetic predisposition to gastric by the CYP1A1 and TNFα genetic biomarkers. The genetic variability was determined by SNPs and RFLP in silico by gene sequences bioinformatic analysis. The environmental and familiar factors were analyzed through surveys. Results. In all our cases (n=10) we found gene risk alleles in high frequency (TNFα 40%, CYP1A1 50%). We observed that the 60% of GC genetic susceptibility were significate associated to age (p<0.05). While the environmental, genetics and familiar did not showed associated to CYP1A1 and TNFα prevalence. An association of smoking with a low genetic variability of the TNFα risk gene was found. Conclusion. The high-risk gene frequencies CYP1A1 and TNFα suggest the presence of gastric cancer human susceptibility in GC diagnosed patients. In the cases observed, the human susceptibility to GC is associated to advanced age and smoking.
Copyright (c) 2024 Cesar Orlando Paz, Jaqueline Mena Huertas, Pablo Fernández Izquierdo, Edith Mariela Burbano-Rosero, Alvaro Pazos
