Published
2022-09-13

How to Cite

Jerez Fernández, C. I. ., Medina Pereira, Y. A. ., Ortiz Chang, A. S. ., González Olmedo, S. I. ., & Aguirre Gaete, M. C. . (2022). Physiopathology and clinical alterations of diabetes mellitus 2: literature review. NOVA Biomedical Sciences Journal, 20(38), 65-103. https://doi.org/10.22490/24629448.6184
Captures
  • Readers: 236
Social Media
  • Shares, Likes & Comments: 10
Metrics
Archivos descargados
12,571
Sep 13 '22Sep 16 '22Sep 19 '22Sep 22 '22Sep 25 '22Sep 28 '22Oct 01 '22Oct 04 '22Oct 07 '22Oct 10 '229
|

Physiopathology and clinical alterations of diabetes mellitus 2

DOI: https://doi.org/10.22490/24629448.6184
Section
Article of Review (before OJS)
Cristhian Ignacio Jerez Fernández
Yerko Alexis Medina Pereira
Amanda Sofía Ortiz Chang
Simón Ignacio González Olmedo
Melany Candy Aguirre Gaete

Type 2 diabetes mellitus is a debilitating, degenerative and multifaceted clinical condition with a high prevalence worldwide. Given the complexity of its pathophysiology and the various therapeutic options that exist, this disease presents a challenge for the general practitioner, it is imperative to understand this pathology to improve its resolution in primary care. After an exhaustive bibliographic search of 103 studies published up to 2010, the most important aspects of both the physiology, pathophysiology, complications, and therapeutics of this pathology were identified. Insulin resistance (IR) is a central metabolic condition in the etiopathogenesis of this pathology. Classically it is possible to recognize both the loss of the peripheral action of insulin by the different tissues as well as defects in the secretion of insulin that leads to constant hyperglycemic states associated with both acute and chronic complications characterized by causing dysfunction and failure in different organs. It is generally known that an important part of the results in the management of this pathology are achieved with changes in lifestyle that range from modifications in diet to changes in the pattern of physical activity with loss of body weight. However, there also is a wide range of pharmacological therapies aimed at controlling hyperglycemic states in the event of the failure of non-pharmacological therapy. Within this same context, there are several therapeutic targets and objectives in the treatment of type 2 diabetics, however, they all converge in the metabolic control of hyperglycemic states and the prevention of their complications.