Published
How to Cite
Prevalence of bacterial resistance isolated in hemocultives, in a university hospital of Colombia
Objective: to describe the frequency of microorganisms and the antibiotic resistance of isolated bacteria in blood cultures of patients with bacteremia, in a university hospital in Colombia. Methods: An observational, descriptive, and cross-sectional study was developed in individuals older than 18 years, where the positive blood cultures were described, isolated in all the services of the University Hospital of the Caribbean. Results: Of the 211 blood cultures analyzed, 53.1% were men. The Gram-positive microorganisms correspond to 49.8%, with a high frequency of S. aureus in 16.1%. Of the Gram negative microorganisms, E.coli was isolated by 18%. Vancomycin resistance was established at 4.4%. K. pneumoniae showed resistance to meropenem in 15.3% of cases. E.coli, P. aeruginosa and E. cloacae are sensitive to carbapenes. Thus, in our study, the bacteria most frequently isolated in the blood cultures were predominantly Gram negative, with resistance to carbapenes for some strains of K. pneumoniae.
Lacoste J, Jarlier V, Coignard B, Vaux S. Estimating the morbidity and mortality associated with infections due to multidrug-resistant bacteria ( MDRB ),. Antimicrob Resist Infect Control [Internet]. 2016;5. Available from: http://dx.doi.org/10.1186/s13756-016-0154-z
Woolhouse M, Waugh C, Perry MR, Nair H. Global disease burden due to antibiotic resistance – state of the evidence. J Glob Health. 2016;6:010306.
Kajumbula H, Fujita AW, Mbabazi O, Najjuka C, Izale C, Akampurira A, et al. Antimicrobial Drug Resistance in Blood Culture Isolates at a Tertiary Hospital, Uganda. Emerg Infect Dis. 2018;24:174–5.
Constanza L, Antolinez D, Bohorquez A, Corredor A. Bacterias anaerobias: procesos que realizan y contribuyen a la sostenibilidad de la vida en el planeta. Nova.2015; 13(24): 55-82.
Fair RJ, Tor Y. Antibiotics and Bacterial Resistance in the 21st Century. Perspect Medicin Chem. 2014;6:25–64.
Worthington RJ, Melander C. Combination Approaches to Combat Multi-Drug Resistant Bacteria. Trends Biotechnol. 2014;31:177–84.
WHO. Plan de acción mundial sobre la resistencia a los antimicrobianos. Geneva, Switzerland: WHO Document Production Services; 2016. p. 1–30.
Powers JH, Evans SR, Aaron S. Studying new antibiotics for multidrug resistant infections : are today ’ s patients paying for unproved future benefits ? BMJ. 2018;360:1–6.
González E, Zapata A, Sánchez-Henao D, Chávez-Vivas M. Resistencia a antibióticos β-lactámicos y eritromicina en bacterias de la cavidad oral. Nova. 2020; 18(34): 27-45.
Cassini A, Högberg LD, Plachouras D, Quattrocchi A, Hoxha A, Simonsen GS. Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015 : a population-level modelling analysis. Lancet Infect Dis. 2019;19:56–66.
WHO. Worldwide country situation analysis : Worldwide country situation analysis : [Internet]. Geneva, Switzerland: WHO Press; 2015. p. 1–43. Available from: www.who.int/drugresistance/en/
WHO. Antimicrobial Resistance [Internet]. Copenhagen: World Health Organization Regional Office for Europe; 2017. p. 1–7. Available from: www.euro.who.int/sdgs ©
Rasheed MU, Thajuddin N, Ahamed P, Teklemariam Z, Jamil K. ANTIMICROBIAL DRUG RESISTANCE IN STRAINS OF Escherichia coli ISOLATED FROM FOOD SOURCES. Rev Inst Med Trop Sao Paulo. 2014;56:341–6.
Farrell DJ, Castanheira M, Mendes RE, Sader HS, Jones RN. In Vitro Activity of Ceftaroline Against Multidrug-Resistant Staphylococcus aureus and Streptococcus pneumoniae : A Review of Published Studies and the AWARE Surveillance Program ( 2008 – 2010 ). 2012;55:206–14.
Reiss-mandel A, Regev-yochay G. Staphylococcus aureus and Streptococcus pneumoniae interaction and response to pneumococcal vaccination : Myth or reality ? 2016;351–7.
González C, Mendoza-medellín A. Resistencia a cefalosporinas de tercera y cuarta generación en enterobacterias productoras de infecciones nosocomiales y caracterización preliminar de los plásmidos involucrados. Cienc ergo sum. 2008;15:83–90.
Karczmarczyk M, Martins M, Quinn T, Leonard N. Mechanisms of Fluoroquinolone Resistance in Escherichia coli Isolates from Food-Producing Animals ᰔ. Appl Environ Microbiol. 2011;77:7113–20.
Rath S, Sc M, Padhy RN, Ph D. Prevalence of fluoroquinolone resistance in Escherichia coli in an Indian teaching hospital and adjoining communities. J Taibah Univ Med Sci [Internet]. 2015;10:504–8. Available from: http://dx.doi.org/10.1016/j.jtumed.2015.02.009
Abdulgader SM, Shittu AO, Nicol MP, Kaba M. Molecular epidemiology of Methicillin-resistant Staphylococcus aureus in Africa : a systematic review. Front Microbiol. 2015;6:348.
Lee AS, Lencastre H De, Garau J, Kluytmans J, Malhotra-kumar S, Peschel A, et al. Methicillin-resistant Staphylococcus aureus. Nat Publ Gr [Internet]. 2018;4:1–23. Available from: http://dx.doi.org/10.1038/nrdp.2018.33
Lee S, Han SW, Kim KW, Song DY, Kwon KT. Third-generation cephalosporin resistance of community-onset Escherichia coli and Klebsiella pneumoniae bacteremia in a secondary hospital. Korean J Int Med. 2014;29:49–56.
Paterson D, Mulazimoglu L, Casellas J. Epidemiology of ciprofloxacin resistance and its relationship to extended-spectrum B-lactamase producing in Klebsiella pneumoniae isolates causing bacteriemia. Clin Infect Dis. 2000; 30: 473-478.
Elshout G, Monteny M, Wouden JC Van Der, Koes BW, Berger MY. Duration of fever and serious bacterial infections in children: a systematic review. BMC Fam Pract [Internet]. 2011;12:33. Available from: http://www.biomedcentral.com/1471-2296/12/33
Pien BC, Sundaram P, Raoof N, Costa SF, Mirrett S. The Clinical and Prognostic Importance of Positive Blood. AJM [Internet]. 2010;123:819–28. Available from: http://dx.doi.org/10.1016/j.amjmed.2010.03.021
Snyder JW. Blood Cultures: the Importance of Meeting Pre-Analytical Requirements in Reducing Contamination, Optimizing Sensitivity of Detection, and Clinical Relevance. Clin Microbiol Newsl [Internet]. 2015;37:53–7. Available from: http://dx.doi.org/10.1016/j.clinmicnews.2015.03.001
Maldonado NA, Múnera MI, López JA, Sierra P, Robledo C, Robledo J, et al. Tendencias de la resistencia a antibióticos en Medellín y en los municipios del área metropolitana entre 2007 y 2012 : resultados de seis años de vigilancia. Biomédica. 2014;34:433–46.
Paz-Montes, América Fuenmayor-Boscán A, Sandrea-Toledo L, Piña-Reyes E, López-Dávila M, Navarro-López P. Incidencia de microorganismos en hemocultivos procesados en un hospital del estado Zulia y su resistencia a los agentes antimicrobianos Incidence of Microorganisms in Blood Cultures Processed at a Hospital in the State of Zulia and Resistance. Kasmera. 2015;43:16–33.
Navon-venezia S, Kondratyeva K, Carattoli A. Klebsiella pneumoniae : a major worldwide source and shuttle for antibiotic resistance. FEMS Microbiol Rev. 2017;41:252–75.
Martin RM, Bachman MA. Colonization , Infection , and the Accessory Genome of Klebsiella pneumoniae. Front Cell Infect Microbiol. 2018;8:4.
Fariña N, Carpinelli L, Samudio M, Guillén R, Laspina F, Sanabria R, et al. Staphylococcus coagulasa-negativa clínicamente significativos. Especies más frecuentes y factores de virulencia. Rev Chil infectología. 2013;30:480–8.
Xu J, Yan C, Wang L, Zhou Q. Changes of Antimicrobial Resistance among Coagulase-Negative Staphylococci Isolated in 8 Consecutive Years in the First Bethune Hospital. Phys Procedia [Internet]. 2012;33:1190–3. Available from: http://dx.doi.org/10.1016/j.phpro.2012.05.195
Duarte-Raya F, Granados-Ramírez MP. Resistencia antimicrobiana de bacterias en un hospital de tercer nivel. Rev Med Inst Mex Seguro Soc. 2012;50:289–300.
Lazo-Arispe GF, Mamani -Flores E, Vargas-Loroño E, Camacho-Aguilar JR, Sahonero-Ampuero O. Sensibilidad y resistencia en el antibiograma del Staphylococcus aureus en pacientes del Hospital Clinico Viedma. Rev Científica Cienc Médica. 2013;16:15–7.
El-zawahry Y, Abdel-shafi S, Zaki M, El-serwy H. Phenotypic and Genotypic Investigation of Methicillin Resistant Staphylococci Species Isolated from Children with Sepsis in Egypt. Egypt J Bot. 2018;58:11–22.
Jeong J, Chang CL, Park TS, Lee SH, Kim SR, Jeong SH. Early Screening of Oxacillin-Resistant Staphylococcus aureus and Staphylococcus epidermidis from Blood Culture. J Korean Med Sci. 2002;17:168–72.
Bennett K, Sharp SE. Rapid Differentiation of Methicillin-Resistant Staphylococcus aureus and Methicillin-Susceptible Staphylococcus aureus from Blood Cultures by Use of a Direct Cefoxitin Disk Diffusion Test ᰔ. J Clin Microbiol. 2008;46:3836–8.
Walter J, Noll I, Feig M, Weiss B, Claus H, Werner G, et al. Decline in the proportion of methicillin resistance among Staphylococcus aureus isolates from non-invasive samples and in outpatient settings , and changes in the co- resistance profiles : an analysis of data collected within the Antimicrobial Resistance. BMC Infect Dis. 2017;17:169.
Adame-g R, Toribio-jimenez J, Vences-velazquez A, Rodr E, Cristina M, Dionisio S, et al. Methicillin-Resistant Staphylococcus aureus (MRSA) in Artisanal Cheeses in México. Int J Microbiol. 2018;2018:6.
Famiglietti A, Quinteros M, Vázquez M, Marín M, Nicola F, Radice M, et al. Consenso sobre las pruebas de sensibilidad a los antimicrobianos en Enterobacteriaceae. Rev Argent Microbiol. 2005;37:57–66.
Turnidge J. Cefazolin and Enterobacteriaceae : Rationale for Revised Susceptibility Testing Breakpoints. Med Microbiol. 2011;52:917–24.
Gutiérrez Lesmes O. Revista CUIDARTE. Rev Cuid. 2015;6:947–54.
Sader HS, Jones RN, Andrade-baiocchi S, Biedenbach DJ, Sentry T, Group P, et al. Four-year evaluation of frequency of occurrence and antimicrobial susceptibility patterns of bacteria from bloodstream infections in Latin American medical centers. Diagn Microbiol Infect Dis. 2003;44:273–80.
Velásquez J, Hernández R, Pamo O, Candiotti M, Pinedo Y, Sacsaquispe R, et al. Klebsiella pneumoniae resistente a los carbapenemes . Primer caso de carbapenemasa tipo KPC en Perú. Rev Soc Peru Med Interna. 2013;26:192–6.
Echeverri-toro LM, Rueda Z V, Maya W, Agudelo Y, Ospina S. Klebsiella pneumoniae. Rev Chil infectología. 2010;29:175–82.
Copyright (c) 2021 NOVA Biomedical Sciences Journal
![Creative Commons License](http://i.creativecommons.org/l/by-nc-nd/4.0/88x31.png)
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
NOVA por http://www.unicolmayor.edu.co/publicaciones/index.php/nova se distribuye bajo una Licencia Creative Commons Atribución-NoComercial-SinDerivar 4.0 Internacional.
Así mismo, los autores mantienen sus derechos de propiedad intelectual sobre los artículos,
Declaración de privacidad.
Los nombres y las direcciones de correo electrónico introducidos en esta revista se usarán exclusivamente para los fines establecidos en ella y no se proporcionarán a terceros o para su uso con otros fines.