Published
2011-06-15

How to Cite

Jaime C., J., Mancipe, L. F., Ramírez, G., & Vera, V. (2011). Cell Culture as an Alternative for Isolation and Production of Biologics Against Influenza Virus. NOVA Biomedical Sciences Journal, 9(15), 83-93. https://doi.org/10.22490/24629448.491
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Cell Culture as an Alternative for Isolation and Production of Biologics Against Influenza Virus

DOI: https://doi.org/10.22490/24629448.491
Section
Article of Review (before OJS)
Jairo Jaime C. Universidad Nacional de Colombia, Sede Bogotá
Luisa Fernanda Mancipe Universidad Nacional de Colombia, Sede Bogotá
Gloria Ramírez Universidad Nacional de Colombia, Sede Bogotá
Víctor Vera Universidad Nacional de Colombia, Sede Bogotá
Influenza Virus has been recognized as an important pathogen in human and animal populations causing many respiratory diseases. Vaccine production and isolation of human and animal influenza viruses are made mainly in chicken embryo eggs, being the conventional method used for decades, however, several issues have been found for vaccine manufacture related with low efficiency of processes due to limited capacity of production (sometimes requiring one or two eggs to obtain a vaccine dose) and time spending that leads to decrease in the ability for fast vaccine production processes in a pandemic situation. The use of continuous cell lines for viral vaccine manufacture rises as a feasible choice offering several advantages including the opportunity to use fully characterized and standardized cells; in addition, cell-culture-derived vaccines don¿t require further planning and vaccines can be produced rapidly. The aim of this paper is to know different alternatives employed in culture and isolation of influenza viruses, emphasizing in the use of cell culture as a substrate for isolation and manufacture of vaccines for use in humans and animals.