Potenciales estrategias terapéuticas basadas en péptidos para mitigar la infección por SARS-CoV-2

Yenny Yolanda Lozano Jiménez; Ruth Mélida Sánchez Mora; Sara Emilia Giraldo Quintero

doi:10.22490/24629448.4187

Vol. 18 No. 35 (2020)

Published 2020-09-25

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Potential Peptide-Based Therapeutic Strategies to Mitigate SARS-COV-2 Infection

DOI: https://doi.org/10.22490/24629448.4187

Yenny Yolanda Lozano Jiménez Universidad de La Salle

Ruth Mélida Sánchez Mora Universidad Colegio Mayor de Cundinamarca

Sara Emilia Giraldo Quintero Universidad de La Salle.

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Abstract
References

The new pandemic by SARS-CoV-2 has encouraged the search for therapeutic alternatives that reduce mortality rates; within these, the use of peptides stands out for its ease of synthesis; easy production on a large scale, specificity in the immune response, versatility in dosage, high purity, economy, among others; offering an excellent option to the traditional approach, failing to evaluate its effectiveness, efficiency and safety at clinical level.

keywords: SARS-CoV-2, peptide, therapeutic strategy, vaccine

Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506.

World Health Organization. Coronavirus disease (COVID-2019) situation reports. Situation report—55. 2020 [ciitado el 17 de junio]. Disponible en: https://www.who.int/docs/default-source/coronaviruse/transcripts/who-audio-emergencies-coronavirus-press-conference-full-and-final-11mar2020.pdf?sfvrsn=cb432bb3_2

Vankadari N, Wilce JA. Emerging COVID-19 coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26. Emerg Microbes Infect [Internet]. 2020 Jan 1;9(1):601–4. DOI: 10.1080/22221751.2020.1739565

Venkatagopalan P, Daskalova SM, Lopez LA, Dolezal KA, Hogue BG. Coronavirus envelope (E) protein remains at the site of assembly. Virology. 2015;478:75–85.

Chan JF-W, Kok K-H, Zhu Z, Chu H, To KK-W, Yuan S, et al. Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. Emerg Microbes Infect. 2020;9(1):221–36.

Li F, Li W, Farzan M, Harrison SC. Structure of SARS coronavirus spike receptor-binding domain complexed with receptor. Science (80). 2005; 309(5742):1864–8.

Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020.

Dutta K. A novel peptide analogue of spike glycoprotein shows antiviral properties against SARS-CoV-2. 2020. DOI: 10.21203/rs.3.rs-32796/v1

Xia S, Liu M, Wang C, Xu W, Lan Q, Feng S, et al. Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion. Cell Res. 2020;30(4):343–55.

Zhang L, Lin D, Sun X, et al. Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors. Science. 2020;368(6489):409-412. doi:10.1126/science.abb3405

Pérez Escoda MT. Diseño y síntesis de péptidos para el diagnóstico de la infección por el virus de la hepatitis G (GBV-C/HGV). Universitat de Barcelona; 2007.

Purcell AW, McCluskey J, Rossjohn J. More than one reason to rethink the use of peptides in vaccine design. Nat Rev Drug Discov. 2007;6(5):404–14.

Pant S, Singh M, Ravichandiran V, Murty USN, Srivastava HK. Peptide-like and small-molecule inhibitors against Covid-19. J Biomol Struct Dyn. 2020;1–10.

Abdelmageed MI, Abdelmoneim AH, Mustafa MI, Elfadol NM, Murshed NS, Shantier SW, et al. Design of a Multiepitope-Based Peptide Vaccine against the E Protein of Human COVID-19: An Immunoinformatics Approach. Biomed Res Int. 2020.

World Health Organization. Proyecto de panorama de las vacunas candidatas COVID-19 [Internet]. 2020 [citado el 17 de junio]. Disponible en: https://www.who.int/publications/m/item/draft-landscape-of-covid-19-candidate-vaccines

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How to Cite

Lozano Jiménez , . Y. Y., Sánchez Mora , R. M., & Giraldo Quintero , S. E. (2020). Potential Peptide-Based Therapeutic Strategies to Mitigate SARS-COV-2 Infection. NOVA Biomedical Sciences Journal, 18(35), 61-66. https://doi.org/10.22490/24629448.4187

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Potential Peptide-Based Therapeutic Strategies to Mitigate SARS-COV-2 Infection

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