Células Dendríticas (CDs) diferenciadas a partir de Monocitos humanos como herramienta para el estudio de agentes antileishmaniales

Gabriela Delgado; Diana Granados

doi:10.22490/24629448.407

Vol. 6 No. 10 (2008)

Published

2008-12-15

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Delgado, G., & Granados, D. (2008). Dendritic Cells From Human Monocytes: As a Tool to Study Antileishmanials Agents. NOVA Biomedical Sciences Journal, 6(10), 162-169. https://doi.org/10.22490/24629448.407

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Dendritic Cells From Human Monocytes: As a Tool to Study Antileishmanials Agents

DOI: https://doi.org/10.22490/24629448.407

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Research Article (before OJS)

Gabriela Delgado Grupo de Investigación en Inmunotoxicología, Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia. Programa Doctoral en Biociencias, Facultad de Ingeniería, Universidad de la Sabana.

Diana Granados Grupo de Investigación en Inmunotoxicología, Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia

Dendritic cells, considered as powerful antigen presenting cells, are fundamental fir the beginning and development of an effective immune response against diverse infections agents. The study of interaction between dendritic cells and parasites is essential for the evaluation and development of new prophylactic and therapeutics strategies able to control the pathogenic agent in a safe and effective way. This is important when considering that different pathogenic agents (e.g. Leishmania parasites) can affect the maturation process and dendritic cells function, as an effective mechanism to evade the immune response.

In this study, it was determined that dendritic cells differentiated from human peripheral blood monocytes (after 72 hours culture in presence of 4 interleukin and granulocyte/macrophage colonies stimulating factor) can successfully be used for evaluation of anti-leishmanial activity and immunomodulator effect of new therapeutics formulations for leishmaniasis control.

cytokines, dendritic cells, interleukin, leishmaniasis, monocytes.

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Dendritic Cells From Human Monocytes: As a Tool to Study Antileishmanials Agents

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