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Pilot study to identify human papillomavirus in patients from Cundinamarca, Colombia, with premalignant lesions and cervical carcinoma
Introduction: Although HPV is considered the causative agent of cervical dysplasia and cancer, some of these cases do not show its presence. Identifyng HPV will provide information that contributes to understanding this condition. Objective: Identify the presence of HPV in cervical biopsies of patients with premalignant lesions and cervical carcinoma, from department to Cundinamarca-Colombia. Methods: 56 cervical biopsies from women to Cundinamarca Public Health Network were included. DNA extraction and quantification were performed, followed by genotyping with the commercial kit (INNO-LiPA HPV Genotyping Extra II). Results: The age range was 26 to 89 years (Md 41; IQR=15). 87.5% were high-grade squamous intraepithelial lesions (HSIL), with an infiltrating squamous cell carcinoma (SCC) being found in an 89-year-old patient. HPV positivity was 79%. 12 high-risk genotypes were identified with predominance of HPV-16 (53%) without HPV-18 being found. In 9% of cases there was coinfection with two genotypes and in 11% the genotype was not included in the kit used. It will be noted that 58% of the identified genotypes are not covered by the currently available vaccines. Conclusions: The finding of the disease in women under 25 and over 65 years of age, as well as the absence of the virus in this type of lesions, raises the need to expand the age range for screening and implement the cotest from the age of 30years. Likewise, the usefulness of paraffinized tissue to detect HPV infection is demonstrated.
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