Efecto citotóxico de una especie nativa de Colombia Bauhinia picta (Fabaceae) en un modelo de línea celular de Glioblastoma

Diana Katherine Garzón-Perdomo; Liliana Francis Turner; Andrea Catalina Rubio Vargas; Laura Alejandra  Lozano Trujillo; Diego Anibal  León Pardo

doi:10.22490/24629448.11768

Vol. 24 No. 47 (2026): 2

Published 2026-06-05

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Cytotoxic effect of a native specie from Colombia Bauhinia picta (Fabaceae) in a Glioblastoma Cell Line Model

DOI: https://doi.org/10.22490/24629448.11768

Diana Katherine Garzón-Perdomo University of Tolima

Liliana Francis Turner University of Tolima

Andrea Catalina Rubio Vargas University of Tolima

Laura Alejandra Lozano Trujillo University of Tolima

Diego Anibal León Pardo University of Tolima

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Abstract
References

Introduction: Glioblastoma is one of the most malignant types of tumors of the nervous system that requires the search for specific and effective therapies that replace the currently used, ones that are not very effective. The specie Bauhinia picta, native to Colombia, has been used for disorders of the circulatory system and has antidiabetic, anti-inflammatory, and antioxidant properties, but has not been evaluated its anticancer activity. Objective: To evaluate the cytotoxic effect of the Bauhinia picta on the Glioblastoma cell line. Results: Our results show that the concentration of 500 μg / ml of this specie is able to decrease the viability of Glioblastoma populations. Conclusion: It is possible that the mechanism of action may be related to the loss of membrane integrity is the interaction between flavonoids present in this specie and the components of this cellular structure.

keywords: Bauhinia picta, cytotoxic effect, glioblastoma, T98

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Garzón-Perdomo, D. K., Francis Turner, L., Rubio Vargas, A. C., Lozano Trujillo, L. A., & León Pardo, D. A. . (2026). Cytotoxic effect of a native specie from Colombia Bauhinia picta (Fabaceae) in a Glioblastoma Cell Line Model. NOVA Biomedical Sciences Journal, 24(47), 11-29. https://doi.org/10.22490/24629448.11768

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Cytotoxic effect of a native specie from Colombia Bauhinia picta (Fabaceae) in a Glioblastoma Cell Line Model

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