Determinación perinatal de leptina en madres y neonatos con diagnóstico de retardo de crecimiento intrauterino (RCIU)

Liliana Muñoz Molina M.Sc.; Juan Carlos Sabogal MD; Clara Arteaga M.Sc.; Rubistein Hernández M.Sc.; Ismena Mockus MD; Jairo Tovar Ph.D

doi:10.22490/24629448.1054

Vol. 1 No. 1 (2003)

Published

2015-05-14

PDF (Spanish)

How to Cite

Muñoz Molina M.Sc., L., Sabogal MD, J. C., Arteaga M.Sc., C., Hernández M.Sc., R., Mockus MD, I., & Tovar Ph.D, J. (2015). Determinación perinatal de leptina en madres y neonatos condiagnóstico de retardo de crecimiento intrauterino (RCIU). NOVA Biomedical Sciences Journal, 1(1), 49-56. https://doi.org/10.22490/24629448.1054

Download Citation

Metrics

Metrics Loading ...

Determinación perinatal de leptina en madres y neonatos condiagnóstico de retardo de crecimiento intrauterino (RCIU)

DOI: https://doi.org/10.22490/24629448.1054

Section

Article (before OJS)

Liliana Muñoz Molina M.Sc. Instituto Materno Infantil de Bogotá, Universidad Colegio Mayor de Cundinamarca

Juan Carlos Sabogal MD Universidad Nacional de Colombia

Clara Arteaga M.Sc. Instituto Materno Infantil de Bogotá, Universidad Nacional de Colombia

Rubistein Hernández M.Sc. Gimnasio Moderno

Ismena Mockus MD Universidad Nacional de Colombia

Jairo Tovar Ph.D Pontificia Universidad Javeriana de Bogotá.

Perinatal determination of Leptin in mothers and neonates with diagnosis of retard of intra-uterine growth (RCIU) Recently it has been described that the leptin presents hormonal activity, acting on receivers and that it isinvolved in the regulation of the metabolic efficiency, spend energy and nutritious ingestion. Has been synthesizedin the sincitiotrofoblastos and it is secreted inside the maternal circulation. The leptin has also been related in thedeposit of fat. Since in the last trimester of the human pregnancy, in a characteristic way a relatively increaseddeposit of fat exists and that this leaves depletado evidently in the cases of RCIU, it is then probable that theleptin keeps relationship with the entity. The objective of this study was to investigate if differences exist among
theleptinmensurations obtained in a group of healthy patients and with RCIU.

The study was carried out in 12 patients with RCIU (cases) and 9 patients without RCIU (you control). For such a reason they took samples of maternal blood and blood cord and of amniotic liquid (THE). In the paired study (n=9) the leptin levels in children born with RCIU presented lower concentrations that the children control (p=0.05). The leptin concentrations in blood cord were correlated significantly with the weight of the neonate (p = 0.0002) and I weigh placentario (p = 0.048). It was not to significant correlation statistically of the leptin levels in maternal blood with the weight of the neonate and the placentario weight. The concentrations of amniotic liquid showed an inverse and statistically significant correlation with the weight neonatal (p = 0.035), but not with the placentario weight (p = 0.071). Inverse and statistically significant correlations were observed among: concentrations of maternal leptin and leptin in blood cord (p = 0.034); cord leptin with leptin in liquid amniotic (p = 0.011) and positive correlation between maternal leptin and leptin in the amniotic fluid (p = 0.01).

Leptin, amniotic fluid, appropiate for gestacional age, maternal serum, blood cord, intrauterinegrowth retarded.

Halaas J, Gajiwala K, Maffei M, Cohen S, Chait B, Rabinowitz D, et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995;269:543-6.

Green E, Maffe M, Braden V, Proenca R, Desilva U, Zhang Y, et al. The human obese (OB) gene: RNA expression pattern and mapping on the physical, cytogenetic, and genetic maps of chromosome 7. Genome Res 1995;5:5-12.

Gong Da-W, Bi Sh, Pratley R,Weintraub D. Genomic structure and promoter analysis of the human obese gene. The J Biol Biochem 1995;271:3971-4.

Zhang F, et al. Crystal structure of the obese protein leptin- E100. Nature 1994;387:206-9.

Schubring C, Kiess W, Englaro P, Rascher W, Dötsch J, Hanitsch S, et al. Levels of leptin in maternal serum, amniotic fluid, and arterial and venous cord blood: relation to neonatal and placental weight. J Clin Endocrinol Metab 1997;82:1480-3.

Tartaglia L. The leptin receptor. J Biol Chem 1997;272:6093-6.

Fey H, Okano H, Li C, Lee G-H, Shako C, Darnell R, et al. Anatomical localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proc Natl Acad Sci USA 1997;94:7001-5.

Schwarts M, Seeley R, Campfield L, Burn P, Baskin D. Identification of targets of leptin in rat hypothalamus. J Clin Invest 1996;98:1101-6.

Chen H, Charlat O, Tartaglia L, Woolf E, Wemg X, Ellis S, et al. Evidence that diabetes Gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice. Cell 1996;84:491-5.

Shimabukuro M, Kazunori K, Chen G, Wang M-Y, Trieu Y, Newgard C, et al. Direct antidiabetic effect of leptin through trygliceride depletion of tissues. Pro Natl Acad Sci USA 1997;94:4637-41.

Blum F, Englaro P, Hanitsch S, Juul A, Hertel N, Müller J, et al. Plasma leptin levels in healthy children and adolescents: dependence on body mass index, body fat mass, gender,

pubertal stage, and testorene. J Endocrinol Metab 1997;82:2904-10.

Masuzaki H, OgawaY, Isse N. Human obese gene expression adiposity-specific expression and regional differences in the adipose tissue. Diabetes 1995;44:855-8.

Hassink S, Sheslow D, Lancey E, Opentanova I, Considine R, Caro J. Serum leptin in children with obesity: relation to gender and development. Pediatrics 1996;98:201-3.

Ahmed M, Ong K, Morrel D, Cox L, Drayer N, Perry L, et al. Longitudinal study of leptin concentrations during puberty: sex differences and relationship to changes in body composition. J Cli Endocrino Metab 1999;84:899-905.

Hoggard N, Hunter L, Duncan J, Williams L, Trayhurn P, Mercer J. Leptin and leptin receptor mRNA and protein expression in the murine fetus and placenta. Proc Natl Acad Sci USA 1997;94:11073-8.

Koistinen H, Koivisto V, Anderson S, Karonen S, Kontula K, Oksanen L, et al. Leptin concentration in cord blood correlates with intrauterine growth. J Clin Endocrinol Metab 1997;82:3328-30.

Harigaya A, Nagashima K, Nako Y, Akihiro M. Relationship between concentration of serum leptin and fetal growth. J Clin Endocrinol Metab 1997;82:3281-4.

Tarquini B, Tarquini R, Perfetto F, Cornélissen G, Halberg F. Genetic and enviromental influences on human cord blood leptin concentration. Pediatrics 1999;103:998-1006.

Matzuda J, Yokota I, Ilda M, Murakami T, Naito E, Ito M, et al. Serum leptin concentration in cord blood: relationship to birth weight and gender. Endocrionl Metab 1997;82:1642-4.

Mercer J, Moar K, Hoggard N. Localization of leptin receptor (Ob-R) messenger Ribonucleic Acid in the rodent hindbrain. Endocrinology 1998;139:29-34.

Anshworth C, Hoggard N, Thomas L, Mercer J, Wallace J, Lea R. Placental leptin. Rev Reprod 2000;84:300-6.

Lewandowski K, Horn R, O’Callaghan C, Dunlop D, Medley G, O’Hare P, et al. Free leptin, bound leptin, and soluble receptor in normal and diabetic pregnancies. J Clin Endocrinol Metab 1999;84:300-6.

Hales C. Metabolic consequences of intrauterine growth retardation. Act Paediart 1997;423 Suppl:184-7.

Tamura T, Robert M, Goldenberg R, Johnston K, Cliver S. Serum leptin concentrations during pregnancy and their relationship to fetal growth. Obstet Gynecol 1998;91:389-95.

Linnemann K, Malek A, Sager R, Blum W, Schneider H, Fusch C. Leptin production and release in the Dually in vitro perfused human placenta. J Endocrinol Metab 2000;85:4298-301.

Download Citation

Published

How to Cite

Determinación perinatal de leptina en madres y neonatos condiagnóstico de retardo de crecimiento intrauterino (RCIU)

Declaración de privacidad.

Keywords