Determinación perinatal de leptina en madres y neonatos con diagnóstico de retardo de crecimiento intrauterino (RCIU)

Liliana Muñoz Molina M.Sc.; Juan Carlos Sabogal MD; Clara Arteaga M.Sc.; Rubistein Hernández M.Sc.; Ismena Mockus MD; Jairo Tovar Ph.D

doi:10.22490/24629448.1054

Vol. 1 No. 1 (2003)

Published 2015-05-14

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Determinación perinatal de leptina en madres y neonatos condiagnóstico de retardo de crecimiento intrauterino (RCIU)

DOI: https://doi.org/10.22490/24629448.1054

Liliana Muñoz Molina M.Sc. Instituto Materno Infantil de Bogotá, Universidad Colegio Mayor de Cundinamarca

Juan Carlos Sabogal MD Universidad Nacional de Colombia

Clara Arteaga M.Sc. Instituto Materno Infantil de Bogotá, Universidad Nacional de Colombia

Rubistein Hernández M.Sc. Gimnasio Moderno

Ismena Mockus MD Universidad Nacional de Colombia

Jairo Tovar Ph.D Pontificia Universidad Javeriana de Bogotá.

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Abstract
References

Perinatal determination of Leptin in mothers and neonates with diagnosis of retard of intra-uterine growth (RCIU) Recently it has been described that the leptin presents hormonal activity, acting on receivers and that it isinvolved in the regulation of the metabolic efficiency, spend energy and nutritious ingestion. Has been synthesizedin the sincitiotrofoblastos and it is secreted inside the maternal circulation. The leptin has also been related in thedeposit of fat. Since in the last trimester of the human pregnancy, in a characteristic way a relatively increaseddeposit of fat exists and that this leaves depletado evidently in the cases of RCIU, it is then probable that theleptin keeps relationship with the entity. The objective of this study was to investigate if differences exist among
theleptinmensurations obtained in a group of healthy patients and with RCIU.

The study was carried out in 12 patients with RCIU (cases) and 9 patients without RCIU (you control). For such a reason they took samples of maternal blood and blood cord and of amniotic liquid (THE). In the paired study (n=9) the leptin levels in children born with RCIU presented lower concentrations that the children control (p=0.05). The leptin concentrations in blood cord were correlated significantly with the weight of the neonate (p = 0.0002) and I weigh placentario (p = 0.048). It was not to significant correlation statistically of the leptin levels in maternal blood with the weight of the neonate and the placentario weight. The concentrations of amniotic liquid showed an inverse and statistically significant correlation with the weight neonatal (p = 0.035), but not with the placentario weight (p = 0.071). Inverse and statistically significant correlations were observed among: concentrations of maternal leptin and leptin in blood cord (p = 0.034); cord leptin with leptin in liquid amniotic (p = 0.011) and positive correlation between maternal leptin and leptin in the amniotic fluid (p = 0.01).

keywords: Leptin, amniotic fluid, appropiate for gestacional age, maternal serum, blood cord, intrauterinegrowth retarded.

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Muñoz Molina M.Sc., L., Sabogal MD, J. C., Arteaga M.Sc., C., Hernández M.Sc., R., Mockus MD, I., & Tovar Ph.D, J. (2015). Determinación perinatal de leptina en madres y neonatos condiagnóstico de retardo de crecimiento intrauterino (RCIU). NOVA Biomedical Sciences Journal, 1(1), 49-56. https://doi.org/10.22490/24629448.1054

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Determinación perinatal de leptina en madres y neonatos condiagnóstico de retardo de crecimiento intrauterino (RCIU)

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