Caracterización de alteraciones en la molécula de hemoglobina en afrodescendientes colombianos

Martha Castillo; Ana Lucia Oliveros

doi:10.22490/24629448.1039

Vol. 12 No. 22 (2014)

Published 2014-12-15

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Research Article (before OJS)

Characterization of molecular alterations of hemoglobin in Afro-Colombians

DOI: https://doi.org/10.22490/24629448.1039

Martha Castillo Universidad Colegio Mayor de Cundinamarca

Ana Lucia Oliveros Universidad Colegio Mayor de Cundinamarca

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Abstract
References

Objective: Characterize molecular alterations of hemoglobin in Afro-Colombian subjects, ranging in age from 18 to 50 years. Analyses were conducted via complete blood count, peripheral blood smear, C-Reactive Protein, serum Ferritin, Soluble Transferrin Receptor (sTfR) and electrophoresis. Materials and Methods: A total of 56 subjects were analyzed, 10 men and 46 women. Results: Subjects (from the Aguablanca District in the City of Cali) showed alterations in the hemoglobin chain associated with Hemoglobin S, Hemoglobin C and possible thalassemias due to Fetal Hemoglobin and augmented Hemoglobin A2. Additionally, a small incidence of subclinical deficiencies of iron at different stages was also detected.

keywords: Afro-Colombian, Hemoglobinopathies, iron deficiencies, anemias.

De Maeyer E, Adiels-Tegman M. The prevalence of anaemia in the world. World Health Stat Q. 1985; 38:302-16.

Durán Cl, Morales Ol, Echeverri Sj, Isaza M. Haplotipos Del Gen De La Globina Beta En Portadores De Hemoglobina S En Colombia. Laboratorio Clínico, Clínica Colsanitas. Biomédica. 2012;32:103-11.

María C. Mondragón A. Capítulo 11 Anemia Falciforme Y Talasemia. En: Francisco Cuellar A, Francisco Falabella F. Fundamentos De Medicina. Hematología. Volumen 6. Colombia. Corporación Para Investigaciones Biológicas. 2004. P. 91

Punnonen K, Irjala K, Rajamäki A. Serum Transferrin Receptor and Its Ratio to Serum Ferritin in the Diagnosis of Iron Deficiency. Blood. 1997; 89(3): 1052-7.

Castillo M, Mora A, Donato K, Pérez F, Tapiero M. Identification of iron deficiency risk by index soluble transferrin receptor-log ferritin in African descent men living at San Basilio de Palenque, Cartagena de Indias, T. and C. D, Bolivar, Colombia. NOVA 2010; 54-62.

Alvear Ciro Cesar, Barboza Miriam, Viola Maricela, Moneriz Carlos, Araque Luz Marina. Pilot Study Of Hemoglobinopathies In Newborns Of The Rafael Calvo Maternity Clinic Of Cartagena, Colombia. Colomb. Med. [Serial On The Internet]. 2012 July; 43(3): 196-199. Available From: Http://Www.Scielo.Org.Co/Scielo.Php?Script=Sci_Arttext&Pid=S1657-95342012000300004&Lng=En.

Restrepo F, Natalia Loaiza, Marcela Arrubla, Sandra Patricia Cossio, Jaime Ordoñez Tamización Neonatal Por Cromatografía De Alta Resolución Para El Diagnóstico De Anemia De Células Falciformes Y Otras Hemoglobinopatías En Medellín, Colombia ISSN 0120-4912. 2011; 43(4).

Gibbons A (2007). “American Association of Physical Anthropologists meeting. European skin turned pale only recently, gene suggests”. Science,316 (5823): 364. DOI:10.1126/ science.316.5823.364a

Suominen P, Punnonoen K, Rajamäki A. Serum transferrin receptor and transferrin receptor–ferritin. Index Identify Healthy Subjects with subclinical iron deficits. Blood. 1998; 92 (8): 2934-39.

Cook JD, Lipschitz DA, Miles LE, Finch CA. Serum ferritin as measure of iron stores in normal subjets. Am J Clin Nutr. 1974; 27:681-7.

Ahluwalia N, Lönnerdal B, Lorenz S, Allen L. Spot ferritin assay for serum simples dried on filter paper. Am J Clin Nutr. 1998; 67:88-92.

Kato J, Kobune M, Kohgo Y, Fujikawa R, Takimoto R, Torimoto Y. Ratio of Transferrin (Tf) to Tf-Receptor Complex in Circulation Differs Depending on Tf Iron Saturation. Clin Chem. 2002; 48:181-3.

Rimon E, Levy S, Sapir A, Gelzer G, Peled R, Ergas D, et al. Diagnosis of iron deficiency anemia in the elderly by transferrin receptor – ferritin index. Arch Intern Med 2002; 162: 445-9.

Choi J. Sensitivity, Specificity, and Predictive Value of Serum Soluble Transferrin Receptor at Different Stages of Iron Deficiency. Ann Clin & Lab Sci. 2005; 35: 435-39.

Svarch E. Fisiopatología De La Drepanocitosis. Revista Cubana De Hematología, Inmunología Y Medicina Transfusional. 2009; 25(1):1-15.

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Castillo, M., & Oliveros, A. L. (2014). Characterization of molecular alterations of hemoglobin in Afro-Colombians. NOVA Biomedical Sciences Journal, 12(22), 151-155. https://doi.org/10.22490/24629448.1039

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Characterization of molecular alterations of hemoglobin in Afro-Colombians

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