Publicado 2023-12-16
Licencia
Artículo original

Morphogenesis of penis and spongy urethra during human gestation

DOI: https://doi.org/10.22490/24629448.7540
Alba Rocío Valencia Universidad Sur Colombiana
Manuel García Florez Universidad Sur Colombiana

Background. Every year, approximately 500,000 children in the world are born with congenital abnormalities of the urinary system and kidneys. Therefore, pediatricians and urologists must understand the normal processes that lead to male sexual differentiation. Objective. The aim of this study was to describe in detail the process that occurs during masculinization of the fetus, which leads to the formation of male structures under normal conditions. Methods. Fifty-four fetuses with gestation periods between four and 18 weeks were collected, which were considered normal, did not have any signs of external anatomic abnormalities or any alteration in their development, and were a product of spontaneous abortions and tubal pregnancies. The urogenital sinus region was collected and prepared for scanning electron microscopy and high-resolution optical microscopy to observe the cellular characteristics of the urogenital fold during external development in male embryos. Results. This work shows the formation of the glans and spongy urethra in a detailed man- ner from the eighth week of embryonic development, carefully describing the role of the labioscrotal folds and the fusion of the walls of the urogenital fold during the subsequent stages of development to form the proximal part of the urinary tract. Conclusion. The for- mation of the penile urethra from the urethral fold and its posterior fusion have a probable role of ectodermal cells, in addition to the endodermal origin established previously.

Palabras clave: Urogenital system, SRY gene, Sex differentiation, Sex determination, Gestational age
Licencia

Derechos de autor 2023 Nova

Creative Commons License

Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-SinDerivadas 4.0.

Cómo citar
Valencia , A. R., & García Florez , M. . (2023). Morphogenesis of penis and spongy urethra during human gestation. Revista Nova publicación científica En Ciencias biomédicas, 21(41). https://doi.org/10.22490/24629448.7540
Almétricas
Métricas
Archivos descargados
106
Dec 16 '23Dec 19 '23Dec 22 '23Dec 25 '23Dec 28 '23Dec 31 '23Jan 01 '24Jan 04 '24Jan 07 '24Jan 10 '24Jan 13 '246.0
|

DECLARACIÓN DE PRIVACIDAD: Según la Ley de Protección de Datos Personales (Ley 1581 de 2012), los nombres y direcciones de correo electrónico manejados por Revista NOVA se usarán exclusivamente para los fines declarados por esta revista y no estarán disponibles para ningún otro propósito u otra persona. Los manuscritos enviados a la publicación solo son conocidos por el equipo editorial y por los pares evaluadores externos.

Diseño e implementado por