Caenorhabditis elegans como modelo de infección para el estudio de antimicrobianos
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Palabras clave

caenorhabditis elegans
modelo
nematodo
bacterias
antimicrobiano
antibióticos
infección

Cómo citar

Rodríguez Morales, D., Lozano Jiménez, Y. Y., & Sánchez Mora, R. M. (2021). Caenorhabditis elegans como modelo de infección para el estudio de antimicrobianos. Nova, 19(36), 109 - 132. https://doi.org/10.22490/24629448.5295

Resumen

A pesar de algunas limitaciones éticas, los animales juegan un papel importante como  anfitriones sustitutos para investigar los mecanismos fisiopatológicos de enfermedades con el fin de indagar en ellos medicamentos contra diferentes patologías. Uno de los grandes problemas en salud pública a nivel mundial en el contexto farmacológico es la producción de antibióticos y la ocurrencia de resistencia microbiana, además, cada vez resulta más omplejo el uso de modelos animales por las restricciones bioéticas actuales, no obstante, es necesario usar modelos simples en los estudios preliminares que permitan evaluar las interacciones huésped-patógeno-antimicrobiano. Al validar que Caenorhabditis elegans es susceptible a varias bacterias y además tiene la capacidad de responder a estímulos ambientales con cambios observables en el comportamiento tras ser alimentado con diversas bacterias, resulta muy útil usarlo en este tipo de investigaciones ya que tiene una vida promedio corta y no cuenta con restricciones éticas para su uso. Por lo anterior, en este artículo se revisa la susceptibilidad que tiene C.elegans de infectarse con diferentes bacterias, además, ya que aún no se ha validado completamente como modelo para poner a prueba antimicrobianos se propone que este nematodo es útil como modelo In vivo para evaluar infecciones y tratamientos antibacterianos. 

https://doi.org/10.22490/24629448.5295
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