Published 2008-12-15
license
Article of Review (before OJS)

Mitochondria and Cell Death

DOI: https://doi.org/10.22490/24629448.409
Gonzalo Arboleda Grupo de Neurociencias, Facultad de Medicina, Universidad Nacional de Colombia. Biotecnología, Universidad Nacional de Colombia. Universidad Colegio Mayor de Cundinamarca, Colombia. Departamento de Patología, Facultad de Medicina, Universidad Nacional de Colombia.
Ruth Melida Sánchez Grupo de Neurociencias, Facultad de Medicina, Universidad Nacional de Colombia. Biotecnología, Universidad Nacional de Colombia. Universidad Colegio Mayor de Cundinamarca, Colombia.
Mitochondria and cell death Recently the decisive role of mitochondria in the mechanisms of cell death has been defined in diverse models, where the permeability of the mitochondrial outer membrane and the important protein release of the intermembrane space of mitochondria are important characteristics that define this process. Specifically pro-apoptosis proteins such as Cytochrome c, Smac/devil among others, are released during early stages of the apoptosis process. The mechanisms by which these proteins are released depend presumably on the cell type and the nature of the stimulus. The activation of caspases (proteases of cysteine) during the early apoptosis seems to mainly be regulated by the family of the Bcl-2 proteins, whose main function is the control of the permeability of the mitochondrial membrane through the formation or regulation of pores, in particular the pore of mitochondrial transitional permeability. This revision intends to show a global vision of the role of mitochondria in the processes of cell death, in apoptosis and in some of the molecular mechanisms involved in its regulation
keywords: apoptosis, caspases, cytochrome c, glycolysis, Krebs cycle, mitochondria.
license
How to Cite
Arboleda, G., & Sánchez, R. M. (2008). Mitochondria and Cell Death. NOVA Biomedical Sciences Journal, 6(10), 190-200. https://doi.org/10.22490/24629448.409
Almétricas
Metrics
Archivos descargados
6,419
Jan 2009Jul 2009Jan 2010Jul 2010Jan 2011Jul 2011Jan 2012Jul 2012Jan 2013Jul 2013Jan 2014Jul 2014Jan 2015Jul 2015Jan 2016Jul 2016Jan 2017Jul 2017Jan 2018Jul 2018Jan 2019Jul 2019Jan 2020Jul 2020Jan 2021Jul 2021Jan 2022Jul 2022Jan 2023Jul 2023Jan 2024Jul 2024Jan 2025Jul 2025Jan 202694
|

PRIVACY STATEMENT: In accordance with the Personal Data Protection Law (Law 1581 of 2012), the names and email addresses managed by Revista NOVA will be used exclusively for the purposes stated by this journal and will not be made available for any other purpose or to any other individual. Manuscripts submitted to the publication are only accessible to the editorial team and external peer reviewers.

Design and implemented by