Efectividad de enjuagues bucales contra virus de la familia coronavirus: Revisión sistemática

Andrea  Álvarez- Ojeda; Ariana Lozada-Martínez; Stella  Pupo Marrugo; Antonio  Díaz-Caballero

doi:10.22490/24629448.6590

Vol. 20 Núm. 39 (2022)

Publicado

2022-12-22

PDF

Métricas

Cargando métricas ...

Efectividad de enjuagues bucales contra virus de la familia coronavirus

DOI: https://doi.org/10.22490/24629448.6590

Sección

Artículo corto

Andrea Álvarez- Ojeda Universidad de Cartagena

Ariana Lozada-Martínez Universidad de Cartagena

Stella Pupo Marrugo Universidad de Cartagena

Antonio Díaz-Caballero Universidad de Cartagena

La aparición del virus Sars-CoV-2 y la enfermedad Covid-19 han provocado un estado de emergencia en el sistema de salud. Teniendo en cuenta el potencial de la saliva como material contaminante, la práctica odontológica fue una de las áreas que se vio afectada debido al uso de instrumentos que pueden esparcir aerosoles y salpicaduras que contienen microorganismos hacia el medio ambiente. Por esta razón, conociendo su potencial en la inactivación de patógenos, se propuso la utilización de enjuagues bucales en la práctica clínica previo a la realización de procedimientos dentales, sin embargo la evidencia no es clara respecto a su efectividad. Objetivo. Establecer el estado de evidencia actual del efecto de los enjuagues bucales sobre los coronavirus que se encuentran en cavidad. Métodos. Se realizó una revisión sistemática siguiendo todos los parámetros descritos en las Directrices
PRISMA basada en información obtenida en los buscadores Science direct, Pubmed y Dentistry and Oral Science Source. Los criterios de selección incluyeron estudios in vivo e in vitro de texto completo que evidenciaron la efectividad del enjuague bucal contra coronavirus. Resultados. Se obtuvieron 90 artículos, de los cuales sólo 12 cumplían con los criterios de inclusión,8 in vitro y 4 in vivo, que fueron sometidos a la evaluación de calidad metodológica utilizando la lista de verificación de evaluación crítica del JBI. Conclusiones. Los resultados sugieren que la povidona yodada es efectiva para la inactivación del virus Sars-coV-2 en todas sus concentraciones.

efectividad, coronavirus, compuesto de amonio cuaternario, peróxido de hidrógeno, povidona yodada

Seyed Hosseini E, Riahi Kashani N, Nikzad H, Azadbakht J, Hassani Bafrani H, Haddad Kashani H. The novel coronavirus Disease-2019 (COVID-19): Mechanism of action, detection and recent therapeutic strategies. Virology [Internet]. 2020 Dec [cited 2021 Jan 24];551:1–9. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513802/

Ge Z yu, Yang L ming, Xia J jia, Fu X hui, Zhang Y zhen. Possible aerosol transmission of COVID-19 and special precautions in dentistry. J Zhejiang Univ Sci B [Internet]. 2020 Mar 16 [cited 2021 Jan 24];1–8. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089481/

Baghizadeh Fini M. What dentists need to know about COVID-19. Oral Oncol [Internet]. 2020 Jun [cited 2020 Oct 12];105:104741. Available from: https://linkinghub.elsevier.com/retrieve/pii/S1368837520301779

To KKW, Sridhar S, Chiu KHY, Hung DLL, Li X, Hung IFN, et al. Lessons learned 1 year after SARS-CoV-2 emergence leading to COVID-19 pandemic. Emerg Microbes Infect [Internet]. [cited 2022 Oct 2];10(1):507– 35. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8006950/

Tu YF, Chien CS, Yarmishyn AA, Lin YY, Luo YH, Lin YT, et al. A Review of SARS-CoV-2 and the Ongoing Clinical Trials. Int J Mol Sci [Internet]. 2020 Apr 10 [cited 2020 Oct 12];21(7). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177898/

Contini C, Nuzzo MD, Barp N, Bonazza A, Giorgio RD, Tognon M, et al. The novel zoonotic COVID-19 pandemic: An expected global health concern. J Infect Dev Ctries [Internet]. 2020 Mar 31 [cited 2021 Jan 24];14(03):254–64. Available from: https://jidc.org/index.php/journal/article/view/32235085

Baghizadeh Fini M. Oral saliva and COVID-19. Oral Oncol [Internet]. 2020 Sep [cited 2021 Jan 20];108:104821. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250788/

Tavares C de AM, Avelino-Silva TJ, Benard G, Cardozo FAM, Fernandes JR, Girardi ACC, et al. ACE2 Expression and Risk Factors for COVID-19 Severity in Patients with Advanced Age. Arq Bras Cardiol [Internet]. 2020 Oct [cited 2021 Jan 24];115(4):701–7. Available from: http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0066-782X2020001200701&lng=en&nrm=iso&tlng=en

Retamal-Valdes B, Soares GM, Stewart B, Figueiredo LC, Faveri M, Miller S, et al. Effectiveness of a preprocedural mouthwash in reducing bacteria in dental aerosols: randomized clinical trial. Braz Oral Res [Internet]. 2017 [cited 2021 Feb 14];31(0). Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-83242017000100221&lng=en&tlng=en

Villani FA, Aiuto R, Paglia L, Re D. COVID-19 and Dentistry: Prevention in Dental Practice, a Literature Review. Int J Environ Res Public Health [Internet]. 2020 Jun [cited 2021 Jan 25];17(12). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344885/

Kohn WG, Collins AS, Cleveland JL, Harte JA, Eklund KJ, Malvitz DM. Guidelines for infection control in dental health-care settings-2003. 2003;

Berry M, Gamieldien J, Fielding BC. Identification of New Respiratory Viruses in the New Millennium. Viruses [Internet]. 2015 Mar 6 [cited 2020 Sep 27];7(3):996–1019. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379558/

Martínez Lamas L, Diz Dios P, Pérez Rodríguez MT, Del Campo Pérez V, Cabrera Alvargonzalez JJ, López Domínguez AM, et al. Is povidone iodine mouthwash effective against SARS-CoV-2? First in vivo tests. Oral Dis. 2020 Jul 2;

Kelly N, Nic Íomhair A, McKenna G. Can oral rinses play a role in preventing transmission of Covid 19 infection? Evid Based Dent. 2020;21(2):42–3.

Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev [Internet]. 2015 Jan 1 [cited 2021 Feb 14];4(1). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320440/

Moola S. Chapter 7: systematic reviews of etiology and risk in: Aromataris E, Munn Z, eds Joanna Briggs institute reviewer’s manual. The Joanna Briggs Institute, 2017.

Negri EC, Mazzo A, Martins JCA, Pereira GA, Almeida RG dos S, Pedersoli CE. Clinical simulation with dramatization: gains perceived by students and health professionals. Rev Lat Am Enfermagem [Internet]. 2017 Aug 3 [cited 2021 Jul 20];25:e2916. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626175/

Santos WM dos, Secoli SR, Püschel VA de A. The Joanna Briggs Institute approach for systematic reviews. Rev Lat Am Enfermagem [Internet]. 2018 Nov 14 [cited 2021 Jul 20];26(0). Available from: http://www. scielo.br/scielo.php?script=sci_arttext&pid=S0104-11692018000100701&lng=en&tlng=en

Mukherjee PK, Esper F, Buchheit K, Arters K, Adkins I, Ghannoum MA, et al. Randomized, double-blind, placebocontrolled clinical trial to assess the safety and effectiveness of a novel dual-action oral topical formulation against upper respiratory infections. BMC Infect Dis. 2017 14;17(1):74.

Seneviratne CJ, Balan P, Ko KKK, Udawatte NS, Lai D, Ng DHL, et al. Efficacy of commercial mouth-rinses on SARS-CoV-2 viral load in saliva: randomized control trial in Singapore. Infection [Internet]. 2020 Dec 14 [cited 2021 Feb 15];1–7. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7734110/

Gottsauner MJ, Michaelides I, Schmidt B, Scholz KJ, Buchalla W, Widbiller M, et al. A prospective clinical pilot study on the effects of a hydrogen peroxide mouthrinse on the intraoral viral load of SARS-CoV-2. Clin Oral Investig [Internet]. 2020 Sep 2 [cited 2020 Oct 6];1–7. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464055/

Eggers M, Koburger-Janssen T, Eickmann M, Zorn J. In Vitro Bactericidal and Virucidal Efficacy of Povidone- Iodine Gargle/Mouthwash Against Respiratory and Oral Tract Pathogens. Infect Dis Ther [Internet]. 2018 Jun [cited 2020 Sep 9];7(2):249–59. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986684/

Eggers M, Eickmann M, Zorn J. Rapid and Effective Virucidal Activity of Povidone-Iodine Products Against Middle East Respiratory Syndrome Coronavirus (MERSCoV) and Modified Vaccinia Virus Ankara (MVA). Infect Dis Ther [Internet]. 2015 Dec [cited 2020 Sep 27];4(4):491–501. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675768/

Pelletier J, Tessema B, Westover J, Frank S, Brown S, Capriotti J. In Vitro Efficacy of Povidone-Iodine Nasal And Oral Antiseptic Preparations Against Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2).edRxiv [Internet]. 2020 May 26 [cited 2020 Oct 6];2020.05.25.20110239. Available from: https://www.medrxiv.org/content/10.1101/2020.05.25.20110239v1

Anderson DE, Sivalingam V, Kang AEZ, Ananthanarayanan A, Arumugam H, Jenkins TM, et al. Povidone-Iodine Demonstrates Rapid In Vitro Virucidal Activity Against SARS-CoV-2, The Virus Causing COVID-19 Disease. Infect Dis Ther. 2020 Sep;9(3):669–75.

Kariwa H, Fujii N, Takashima I. Inactivation of SARS coronavirus by means of povidone-iodine, physical conditions and chemical reagents. Dermatol Basel Switz. 2006;212 Suppl 1:119–23.

Bidra AS, Pelletier JS, Westover JB, Frank S, Brown SM, Tessema B. Rapid In‐Vitro Inactivation of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) Using Povidone‐Iodine Oral Antiseptic Rinse. J Prosthodont [Internet]. 2020 Jul [cited 2020 Sep 9];29(6):529–33. Available from: https://onlinelibrary.wiley.com/doi/abs/10.1111/jopr.13209

Bidra AS, Pelletier JS, Westover JB, Frank S, Brown SM, Tessema B. Comparison of In Vitro Inactivation of SARS CoV-2 with Hydrogen Peroxide and Povidone-Iodine Oral Antiseptic Rinses. J Prosthodont [Internet]. 2020 [cited 2020 Sep 9];29(7):599–603. Available from: https://onlinelibrary.wiley.com/doi/abs/10.1111/jopr.13220

Wood A, Payne D. The action of three antiseptics/ disinfectants against enveloped and non-enveloped viruses. J Hosp Infect. 1998 Apr;38(4):283–95.

Baker N, Williams AJ, Tropsha A, Ekins S. Repurposing Quaternary Ammonium Compounds as Potential Treatments for COVID-19. Pharm Res [Internet]. 2020 [cited 2022 Oct 2];37(6):104. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247743/

Reis INR, do Amaral GCLS, Mendoza AAH, das Graças YT, Mendes-Correa MC, Romito GA, et al. Can preprocedural mouthrinses reduce SARS-CoV-2 load in dental aerosols? Med Hypotheses [Internet]. 2021 Jan [cited 2022 Oct 2];146:110436. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691843/

Moosavi MS, Aminishakib P, Ansari M. Antiviral mouthwashes: possible benefit for COVID-19 with evidence-based approach. J Oral Microbiol [Internet]. [cited 2020 Sep 29];12(1). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482897/

Carrouel F, Conte MP, Fisher J, Gonçalves LS, Dussart C, Llodra JC, et al. COVID-19: A Recommendation to Examine the Effect of Mouthrinses with β-Cyclodextrin Combined with Citrox in Preventing Infection andProgression. J Clin Med [Internet]. 2020 Apr 15 [cited 2022 Sep 30];9(4):1126. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230644/

Vergara-Buenaventura A, Castro-Ruiz C. Use of mouthwashes against COVID-19 in dentistry. Br J Oral Maxillofac Surg [Internet]. 2020 Oct [cited 2021 Jan 20];58(8):924–7. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428696/

Elzein R, Abdel-Sater F, Fakhreddine S, Hanna PA, Feghali R, Hamad H, et al. In vivo evaluation of the virucidal efficacy of chlorhexidine and povidone-iodine mouthwashes against salivary SARS-CoV-2. A randomized-controlled clinical trial. J Evid-Based Dent Pract [Internet]. 2021 Sep [cited 2022 Sep 30];21(3):101584. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080510/

Huang YH, Huang JT. Use of chlorhexidine to eradicate oropharyngeal SARS‐CoV‐2 in COVID‐19 patients. J Med Virol [Internet]. 2021 Jul [cited 2022 Sep 30];93(7):4370– 3. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251493/

Natto ZS, Bakhrebah MA, Afeef M, Al-Harbi S, Nassar MS, Alhetheel AF, et al. The short-term effect of different chlorhexidine forms versus povidone iodine mouth rinse in minimizing the oral SARS-CoV-2 viral load: An open label randomized controlled clinical trial study. Medicine (Baltimore) [Internet]. 2022 Jul 29 [cited 2022 Sep 30];101(30):e28925. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9333084/

Davies K, Buczkowski H, Welch SR, Green N, Mawer D, Woodford N, et al. Effective in vitro inactivation of SARS-CoV-2 by commercially available mouthwashes. J Gen Virol [Internet]. 2021 Apr 29 [cited 2022 Sep 30];102(4):001578. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8290272/

Peng X, Xu X, Li Y, Cheng L, Zhou X, Ren B. Transmission routes of 2019-nCoV and controls in dental practice. Int J Oral Sci [Internet]. 2020 Mar 3 [cited 2021 May 8];12. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054527/

Goyal SM, Chander Y, Yezli S, Otter JA. Evaluating the virucidal efficacy of hydrogen peroxide vapour. J Hosp Infect [Internet]. 2014 Apr [cited 2022 Sep 30];86(4):255– 9. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132520/

Cervantes Trejo A, Castañeda ID, Rodríguez AC, Andrade Carmona VR, Mercado MDPC, Vale LS, et al. Hydrogen Peroxide as an Adjuvant Therapy for COVID-19: A Case Series of Patients and Caregivers in the Mexico City Metropolitan Area. Evid-Based Complement Altern Med ECAM. 2021;2021:5592042.

Popkin DL, Zilka S, Dimaano M, Fujioka H, Rackley C, Salata R, et al. Cetylpyridinium Chloride (CPC) Exhibits Potent, Rapid Activity Against Influenza Viruses in vitro and in vivo. Pathog Immun [Internet]. 2017 Jun 26 [cited 2022 Sep 30];2(2):253–69. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605151/

Takeda R, Sawa H, Sasaki M, Orba Y, Maishi N, Tsumita T, et al. Antiviral effect of cetylpyridinium chloride in mouthwash on SARS-CoV-2. Sci Rep [Internet]. 2022 Aug 18 [cited 2022 Sep 30];12:14050. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9386671/

Okamoto N, Saito A, Okabayashi T, Komine A. Virucidal activity and mechanism of action of cetylpyridinium chloride against SARS-CoV-2. J Oral Maxillofac Surg Med Pathol [Internet]. 2022 Nov [cited 2022 Sep 30];34(6):800–4. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9010230/

Eduardo F de P, Corrêa L, Heller D, Daep CA, Benitez C, Malheiros Z, et al. Salivary SARS-CoV-2 load reduction with mouthwash use: A randomized pilot clinical trial. Heliyon [Internet]. 2021 Jun 18 [cited 2022 Sep 30];7(6):e07346. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8222261/

Jing JLJ, Pei Yi T, Bose RJC, McCarthy JR, Tharmalingam N, Madheswaran T. Hand Sanitizers: A Review on Formulation Aspects, Adverse Effects, and Regulations. Int J Environ Res Public Health [Internet]. 2020 May [cited 2021 Feb 15];17(9). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246736/

Khan MM, Parab SR, Paranjape M. Repurposing 0.5% povidone iodine solution in otorhinolaryngology practice in Covid 19 pandemic. Am J Otolaryngol [Internet]. 2020 [cited 2022 Oct 1];41(5):102618. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301800/

Naqvi SHS, Citardi MJ, Cattano D, Ostrosky-Zeichner L, Knackstedt MI, Karni RJ. Povidone-iodine solution as SARS-CoV-2 prophylaxis for procedures of the upper aerodigestive tract a theoretical framework. J Otolaryngol - Head Neck Surg [Internet]. 2020 Oct 27 [cited 2022 Oct 1];49:77. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590913/

Ferrer MD, Barrueco ÁS, Martinez-Beneyto Y, Mateos- Moreno MV, Ausina-Márquez V, García-Vázquez E, et al. Clinical evaluation of antiseptic mouth rinses to reduce salivary load of SARS-CoV-2. Sci Rep [Internet]. 2021 Dec 22 [cited 2022 Oct 1];11:24392. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8695582/

Testori T, Wang HL, Basso M, Bordini G, Dian A, Vitelli C, Miletic I, Del Fabbro M.COVID-19 and Oral Surgery: A narrative review of preoperative mouth rinses [Internet].[cited 2021 May 8]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7871429/

Álvarez- Ojeda, A. ., Lozada-Martínez, A., Pupo Marrugo, S. ., & Díaz-Caballero, A. . (2022). Efectividad de enjuagues bucales contra virus de la familia coronavirus: Revisión sistemática. Nova, 20(39), 105-120. https://doi.org/10.22490/24629448.6590

Descargar cita

Derechos de autor 2022 Nova

Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-SinDerivadas 4.0.

Publicado

Efectividad de enjuagues bucales contra virus de la familia coronavirus

Declaración de privacidad.

Palabras clave