Cultivos Celulares como Alternativa para el Aislamiento y la Producción de Biológicos Contra el Virus de Influenza
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Palabras clave

cultivos celulares
huevos embrionados
aislamiento
vacunas
virus de influenza.

Cómo citar

Jaime C., J., Mancipe, L. F., Ramírez, G., & Vera, V. (2011). Cultivos Celulares como Alternativa para el Aislamiento y la Producción de Biológicos Contra el Virus de Influenza. Nova, 9(15), 83-93. https://doi.org/10.22490/24629448.491

Resumen

El virus de influenza ha sido reconocido como un importante patógeno en poblaciones humanas y animales, ya que es el principal causante de enfermedades respiratorias. Muchas vacunas y aislamientos de virus de influenza humana y animal son realizadas actualmente en huevos embrionados, siendo este el método usado tradicionalmente por décadas. Sin embargo, se han encontrado inconvenientes en la elaboración de vacunas ya que el proceso de fabricación es de capacidad limitada (se requiere aproximadamente un huevo para generar una dosis vacunal) y alta demanda tiempo, disminuyendo su habilidad para generar biológicos rápidamente en el caso de una pandemia. El empleo de líneas celulares continuas para la producción de vacunas virales nace como alternativa que ofrece diversas ventajas: (i) oportunidad de emplear células completamente caracterizadas y estandarizadas, (ii) producción y planeación permanente de vacunas y (iii) los biológicos pueden ser producidos de forma más rápida.

El objetivo de esta revisión es analizar las diferentes alternativas empleadas en el cultivo y/o aislamiento de virus de influenza, enfatizando en el uso de cultivos celulares como sustrato para el aislamiento y la producción de biológicos destinados a la salud humana y animal.

https://doi.org/10.22490/24629448.491
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