Published
2024-09-20

How to Cite

Zamora-Pava, J. C., Salamanca Neita, L. H., & Ramírez-López, L. X. (2024). Urine sample as a biomarker for human papillomavirus detection. Biociencias, 7(1), 56-69. https://doi.org/10.22490/26194759.8573
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Urine sample as a biomarker for human papillomavirus detection

DOI: https://doi.org/10.22490/26194759.8573
Section
Artículos
Juan Camilo Zamora-Pava Universidad de Boyacá
Lorenzo Hernando Salamanca Neita Carvajal Laboratorios IPS SAS
Laura Ximena Ramírez-López Universidad de Boyacá

Introduction: The use of urine samples for the detection or screening of cer­vical cancer based on Human Papillomavirus has had high acceptability by women, being a non-invasive method. This study evaluates the performance of testing for Human Papillomavirus in urine samples compared to cervicovaginal samples as a Gold Standard. Methods: A non-systematic review of the scien­tific literature was carried out in order to compile information on published research results related to Human Papillomavirus and the use of urine samples as a biomarker for the diagnosis of cervical cancer, in databases such as Pub­Med, Scopus, Lilacs and Web of Science. Results: In the 13 selected articles, the number of participants in each study ranged from 5 to 543 women, aged 18 to 82 years. The sensitivity and specificity in cervicovaginal samples reported were 63.9% to 95% and 32.69% to 95% respectively, while the sensitivity range in urine samples was 48.1% to 93% and specificity 32.14% to 97%. Discussion: The results of this study demonstrate that urine is a sample that can be used in screening tests for Human Papillomavirus infection, which should be subjected to further testing to increase its diagnostic accuracy.