Resistencia Antimicrobiana: Desafíos Contemporáneos y Estrategias Terapéuticas Innovadoras en la Era Post-Antibiótica

Olga Lucia Ostos Ortiz

doi:10.22490/26194759.10817

Vol. 9 No. 1 (2025): .

Published 2025-12-01

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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Artículos

Antimicrobial Resistance in the Post-Antibiotic Era: Molecular Mechanisms, Emerging Therapeutics, and Evidence-Based Stewardship Implementation in Latin America

DOI: https://doi.org/10.22490/26194759.10817

Olga Lucia Ostos Ortiz Universidad Nacional Abierta y a Distancia

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Abstract
References

Objective: To comprehensively examine molecular mechanisms of antimicrobial resistance, emerging therapeutic strategies, and evidence-based preventive approaches, with particular emphasis on the epidemiological situation in Latin America and Colombia. Method: A narrative literature review was conducted of scientific publications from 2019-2025, using PubMed, SciELO, and specialized repositories. Studies on resistance mechanisms, novel antimicrobial therapies, stewardship programs, epidemiological surveillance, and Latin America-specific data were included. The search incorporated MeSH terms related to antimicrobial resistance, β-lactamases, antimicrobial stewardship, and innovative therapies. Results: Resistance mechanisms include enzymatic modification, molecular target alteration, efflux pumps, and biofilm formation. Novel β-lactam/β-lactamase inhibitor combinations demonstrated efficacy against multidrug-resistant pathogens: cefepime/enmetazobactam for ESBL-producing P. aeruginosa and aztreonam/avibactam for carbapenem-resistant Enterobacterales.. Conclusion. Artificial intelligence accelerated discovery with compounds like halicin and abaucin.

keywords: antimicrobial resistance, β-lactamases,, precision medicine, β-lactamases, antimicrobial

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How to Cite

Ostos Ortiz, O. L. (2025). Antimicrobial Resistance in the Post-Antibiotic Era: Molecular Mechanisms, Emerging Therapeutics, and Evidence-Based Stewardship Implementation in Latin America. Biociencias, 9(1), 53-68. https://doi.org/10.22490/26194759.10817

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