Exploración de la Relación del Virus Varicela-Zoster (VVZ)  y Enfermedad de Alzheimer (EA)

Brenda Michelly Camargo Gonzalez; Sally Milena Martinez Martinez; Johanna Lizeth Gonzalez Devia

doi:10.22490/26194759.10407

Vol. 8 No. 1 (2024)

Published 2024-12-27

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Artículos

Exploration of the Relationship of Varicella-Zoster Virus (VZV) and Alzheimer’s Disease (AD)

DOI: https://doi.org/10.22490/26194759.10407

Brenda Michelly Camargo Gonzalez Universidad Colegio Mayor de Cundinamarca

Sally Milena Martinez Martinez Universidad Colegio Mayor de Cundinamarca

Johanna Lizeth Gonzalez Devia Universidad Colegio Mayor de Cundinamarca

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Abstract
References

Introduction: Alzheimer’s disease (AD) is a neurodegenerative disorder with a multifactorial etiology. Among the proposed causes, a viral origin has been considered, particularly involving Herpes Simplex Virus type 1 (HSV-1) and Varicella-Zoster Virus (VZV). Reactivation of VZV in individuals over 65 years of age has been suggested as a potential trigger of neuroinflammation, which may contribute to the development of AD. Objective: To analyze the existing scientific literature in order to evaluate a possible relationship between VZV reactivation and the development of Alzheimer’s disease. Methods: A systematic review was conducted following the PRISMA guidelines, based on published studies related to VZV and AD. Results: VZV reactivation can lead to various alterations in the central nervous system, including dementia, through mechanisms such as neuroinflammation, vasculopathy, and direct neuronal damage. Conclusions: Although progress has been made in understanding the impact of VZV on the central nervous system, further research is needed to clarify its role in neurodegenerative diseases such as AD. Current evidence does not confirm a definitive link between VZV and Alzheimer’s disease, but neither does it exclude its possible involvement.

keywords: Varicella-Zoster Virus, Herpes Zoster, Alzheimer’s Disease, Neurodegenerative Disease, Encephalitis, Neuroinflammation

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How to Cite

Camargo Gonzalez , B. M., Martinez Martinez , S. M., & Gonzalez Devia , J. L. (2024). Exploration of the Relationship of Varicella-Zoster Virus (VZV) and Alzheimer’s Disease (AD). Biociencias, 8(1), 48-64. https://doi.org/10.22490/26194759.10407

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